このエントリーをはてなブックマークに追加
ID 57940
フルテキストURL
著者
Ikeda, Tomoka Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Gion, Yuka Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Sato, Yasuharu Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
抄録
Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous regression. Histologically, EBVMCUs are characterized by the proliferation of EBV-positive, variable-sized, atypical B-cells. According to conventional histopathologic criteria, EBVMCUs may diagnosed as lymphomas. However, EBVMCUs are recognized as pseudomalignant lesions because they spontaneously regress without anti-cancer treatment. Therefore, overtreatment must be carefully avoided and multilateral differentiation is important. In this article, we reviewed previously reported EBVMCUs focusing on their clinical and pathological aspects in comparison with other EBV-positive B-cell neoplasms.
キーワード
EBV-positive mucocutaneous ulcer
clinical features
immunosuppression
pathological features
発行日
2019-06-28
出版物タイトル
Journal of Clinical and Experimental Hematopathology
59巻
2号
出版者
Japanese Society for Lymphoratic Tissue Research
開始ページ
64
終了ページ
6471
ISSN
1346-4280
NCID
AA11556796
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3960/jslrt.18039
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Tomoka Ikeda, Yuka Gion, Tadashi Yoshino, Yasuharu Sato, A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects, Journal of Clinical and Experimental Hematopathology, 2019, Volume 59, Issue 2, Pages 64-71, Released June 28, 2019, Online ISSN 1880-9952, Print ISSN 1346-4280, https://doi.org/10.3960/jslrt.18039