start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=5
article-no=
start-page=387
end-page=399
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Radon Inhalation on Murine Brain Proteins: Investigation Using Proteomic and Multivariate Analyses
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon is a known risk factor for lung cancer; however, it can be used beneficially, such as in radon therapy. We have previously reported the enhancement of antioxidant effects associated with trace amounts of oxidative stress as one of the positive biological effects of radon inhalation. However, the biological effects of radon inhalation are incompletely understood, and more detailed and comprehensive studies are required. Although several studies have used proteomics to investigate the effects of radon inhalation on body proteins, none has focused on brain proteins. In this study, we evaluated the expression status of proteins in murine brains using proteomic and multivariate analyses to identify those whose expressions changed following two days of radon inhalation at a concentration of 1,500 Bq/m3. We found associations of radon inhalation with the expressions of seven proteins related to neurotransmission and heat shock. These proteins may be proposed as biomarkers indicative of radon inhalation. Although further studies are required to obtain the detailed biological significance of these protein alterations, this study contributes to the elucidation of the biological effects of radon
inhalation as a low-dose radiation.
en-copyright=
kn-copyright=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TanakaAyumi
en-aut-sei=Tanaka
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TakenakaReiju
en-aut-sei=Takenaka
en-aut-mei=Reiju
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MiyajiTakaaki
en-aut-sei=Miyaji
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=6
en-affil=Advanced Science Research Center, Okayama University
kn-affil=
affil-num=7
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=proteomics
kn-keyword=proteomics
en-keyword=multivariate analysis
kn-keyword=multivariate analysis
en-keyword=brain
kn-keyword=brain
en-keyword=oxidative stress
kn-keyword=oxidative stress
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=387
end-page=394
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ? 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HabuHiroshi
en-aut-sei=Habu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TanakaAyumi
en-aut-sei=Tanaka
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MurakamiKaito
en-aut-sei=Murakami
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=FujimotoYuki
en-aut-sei=Fujimoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YukimineRyohei
en-aut-sei=Yukimine
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=TakaoSoshi
en-aut-sei=Takao
en-aut-mei=Soshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=2
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=4
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=5
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=6
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=7
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
affil-num=8
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Longevity and Social Medicine (Geriatrics), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Sciences
kn-affil=
en-keyword=radon hot spring
kn-keyword=radon hot spring
en-keyword=bathing habit
kn-keyword=bathing habit
en-keyword=self-rated health
kn-keyword=self-rated health
en-keyword=cross-section study
kn-keyword=cross-section study
END
start-ver=1.4
cd-journal=joma
no-vol=64
cd-vols=
no-issue=4
article-no=
start-page=635
end-page=643
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230517
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The liver's susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate gamma-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors-liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.
en-copyright=
kn-copyright=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=FujimotoYuki
en-aut-sei=Fujimoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MurakamiKaito
en-aut-sei=Murakami
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YukimineRyohei
en-aut-sei=Yukimine
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TanakaAyumi
en-aut-sei=Tanaka
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
en-keyword=low-dose/high-dose-rate irradiation
kn-keyword=low-dose/high-dose-rate irradiation
en-keyword=forced swim test
kn-keyword=forced swim test
en-keyword=alcohol
kn-keyword=alcohol
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=antioxidants
kn-keyword=antioxidants
END
start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=17
article-no=
start-page=10632
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220826
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Typical indications for radon therapy include autoimmune diseases such as rheumatoid arthritis (RA). We had previously reported that radon inhalation inhibits Th17 immune responses in RA mice by activating Th1 and Th2 immune responses. However, there are no reports on how radon inhalation affects the activated Th1 and Th17 immune responses, and these findings may be useful for identifying new indications for radon therapy. Therefore, in this study, we investigated the effect of radon inhalation on the lipopolysaccharide (LPS)-induced inflammatory response, focusing on the expression of related cytokines and antioxidant function. Male BALB/c mice were exposed to 2000 Bq/m(3) radon for one day. Immediately after radon inhalation, LPS was administered intraperitoneally at 1.0 mg/kg body weight for 4 h. LPS administration increased the levels of Th1- and Th17-prone cytokines, such as interleukin-2, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor, compared to no treatment control (sham). However, these effects were suppressed by radon inhalation. IL-10 levels were significantly increased by LPS administration, with or without radon inhalation, compared to sham. However, radon inhalation did not inhibit oxidative stress induced by LPS administration. These findings suggest that radon inhalation has immunomodulatory but not antioxidative functions in LPS-induced injury.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MurakamiKaito
en-aut-sei=Murakami
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=FujimotoYuki
en-aut-sei=Fujimoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YukimineRyohei
en-aut-sei=Yukimine
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TanakaAyumi
en-aut-sei=Tanaka
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
en-keyword=autoimmune diseases
kn-keyword=autoimmune diseases
en-keyword=cytokine
kn-keyword=cytokine
en-keyword=antioxidant function
kn-keyword=antioxidant function
en-keyword=lipopolysaccharide
kn-keyword=lipopolysaccharide
en-keyword=radon inhalation
kn-keyword=radon inhalation
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220711
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m(3) and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m(3)) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m(3) thoron inhalation was lower than that after 500 Bq/m(3) thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m(3) and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m(3) was more effective than that at 2000 Bq/m(3), possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m(3) and AA administration promoted an early recovery from alcohol-induced liver damage.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=IshidaTsuyoshi
en-aut-sei=Ishida
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=5
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=7
en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=alcohol-induced liver damage
kn-keyword=alcohol-induced liver damage
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=antioxidative function
kn-keyword=antioxidative function
en-keyword=ascorbic acid (AA)
kn-keyword=ascorbic acid (AA)
en-keyword=thoron
kn-keyword=thoron
END
start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=2
article-no=
start-page=87
end-page=92
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Indications of radon therapy include various diseases related to respiratory, painful, digestive, chronic degenerative, senile, etc. derived from reactive oxygen species, but most are based on empirical prescriptions. For this reason, we have evaluated the relation between the biological response caused by radon and the tissue/organ absorbed dose more quantitatively, and have promoted the elucidation of mechanisms related to the indication and searching newly. As a result, as a mechanism, a series of moderate physiological stimulative effects accompanying a small amount of oxidative stress by radon inhalation are being elucidated. That is, hyperfunction of anti-oxidation/immune regulation/damage repair, promotion of anti-inflammation/circulating metabolism/hormone secretion, induction of apoptosis/heat shock protein, etc. Also, new indications include inflammatory/neuropathic pain, hepatic/renal injury, colitis, type 1 diabetes, complication kidney injury, hyperuricemia, transient cerebral ischemia, and inflammatory edema. Furthermore, we examined the combined antioxidant effect of radon inhalation and antioxidants or therapeutic agents. As a result, it was clear that any combination treatment could enhance the suppression effect of disease. It can be expected that radon therapy can be used effectively by applying it in addition to usual treatment, since reduction in its dosage can also be expected by concomitant use for drugs with strong side effects.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
affil-num=1
en-affil=Health Sciences, Institute of Academic and Research, Okayama University
kn-affil=
affil-num=2
en-affil=Health Sciences, Institute of Academic and Research, Okayama University
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=2
article-no=
start-page=154
end-page=159
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000?Bq/m3 for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000?Bq/m3 for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MurakamiKaito
en-aut-sei=Murakami
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YukimineRyohei
en-aut-sei=Yukimine
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=FujimotoYuki
en-aut-sei=Fujimoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=7
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=8
en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=radon
kn-keyword=radon
en-keyword=cytokine
kn-keyword=cytokine
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=rheumatoid arthritis
kn-keyword=rheumatoid arthritis
en-keyword=immunomodulation function
kn-keyword=immunomodulation function
END
start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=5
article-no=
start-page=861
end-page=867
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210809
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m(3) (for one, three, or 10 days). The 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m(3) radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m(3) radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m(3) for three days or 20 kBq/m(3) for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShutoHina
en-aut-sei=Shuto
en-aut-mei=Hina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YanoJunki
en-aut-sei=Yano
en-aut-mei=Junki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=TeratoHiroaki
en-aut-sei=Terato
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=7
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=8
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=10
en-affil=Advanced Science Research Center Okayama University
kn-affil=
affil-num=11
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=radon
kn-keyword=radon
en-keyword=oxidative DNA damage
kn-keyword=oxidative DNA damage
en-keyword=Mn-superoxide dismutase (SOD)
kn-keyword=Mn-superoxide dismutase (SOD)
en-keyword=8-oxoguanine DNA glycosylase
kn-keyword=8-oxoguanine DNA glycosylase
END
start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=3
article-no=
start-page=390
end-page=400
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of the redox state in mouse organs following radon inhalation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m(3) for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ShutoHina
en-aut-sei=Shuto
en-aut-mei=Hina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YanoJunki
en-aut-sei=Yano
en-aut-mei=Junki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TeratoHiroaki
en-aut-sei=Terato
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=3
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=8
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Advanced Science Research Center, Okayama University
kn-affil=
affil-num=10
en-affil=Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=11
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=radon
kn-keyword=radon
en-keyword=redox state
kn-keyword=redox state
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=antioxidative function
kn-keyword=antioxidative function
en-keyword=principal component analysis
kn-keyword=principal component analysis
END
start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=4
article-no=
start-page=517
end-page=523
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200429
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShutoHina
en-aut-sei=Shuto
en-aut-mei=Hina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YanoJunki
en-aut-sei=Yano
en-aut-mei=Junki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=IshidaTsuyoshi
en-aut-sei=Ishida
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NakadaTetsuya
en-aut-sei=Nakada
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Laboratory of Neurology and Neurosurgery, National Cerebral and Cardiovascular Center
kn-affil=
affil-num=8
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Central Research Institute of Electric Power Industry
kn-affil=
affil-num=10
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=X-irradiation
kn-keyword=X-irradiation
en-keyword=forced swim test
kn-keyword=forced swim test
en-keyword=antioxidants
kn-keyword=antioxidants
en-keyword=brain
kn-keyword=brain
en-keyword=oxidative stress
kn-keyword=oxidative stress
END
start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=3
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200422
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of antioxidative effects between radon and thoron inhalation in mouse organs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.
en-copyright=
kn-copyright=
en-aut-name=KobashiYusuke
en-aut-sei=Kobashi
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=IshidaTsuyoshi
en-aut-sei=Ishida
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=
affil-num=7
en-affil=Prototype Fast Breeder Reactor Monju, Japan Atomic Energy Agency
kn-affil=
affil-num=8
en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=Radon
kn-keyword=Radon
en-keyword=Thoron
kn-keyword=Thoron
en-keyword=Oxidative stress
kn-keyword=Oxidative stress
en-keyword=Antioxidative function
kn-keyword=Antioxidative function
END
start-ver=1.4
cd-journal=joma
no-vol=2012
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=2012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.
en-copyright=
kn-copyright=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci
affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci
affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci
affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci
affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci
END
start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=6
article-no=
start-page=830
end-page=839
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl(4))-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl(4)-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl(4) after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl(4)-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl(4) alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl(4)-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TeraokaJunichi
en-aut-sei=Teraoka
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MoriiYuji
en-aut-sei=Morii
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=7
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=Radon
kn-keyword=Radon
en-keyword=ascorbic acid
kn-keyword=ascorbic acid
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=antioxidant
kn-keyword=antioxidant
en-keyword=hepatopathy
kn-keyword=hepatopathy
END
start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=9
article-no=
start-page=1181
end-page=1187
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone’s attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300?500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MoriiYuji
en-aut-sei=Morii
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=EtaniReo
en-aut-sei=Etani
en-aut-mei=Reo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TakataYuji
en-aut-sei=Takata
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KawabeAtsuishi
en-aut-sei=Kawabe
en-aut-mei=Atsuishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=10
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=11
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=12
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radon
kn-keyword=radon
en-keyword=carbon tetrachloride
kn-keyword=carbon tetrachloride
en-keyword=oxidative damage
kn-keyword=oxidative damage
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=kidney
kn-keyword=kidney
END
start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic Study on Positive Effects of Radon Inhalation on Pet's Health
kn-title=ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=Radon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500Bq/m3 for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure.
kn-abstract=著者らは今までに，共同開発したラドン吸入装置を用いマウスにラドン吸入をさせた場合，諸臓器中の抗酸化機能が亢進する可能性などを明らかにしてきた。本研究では，ラドン吸入の獣医療への応用の可能性について新たに検討するため，健常なイヌ5頭(オス：2(1，9才)，メス：3(1〜5才))及び慢性腎不全症のネコ8頭(オス：3(2〜6才)，メス：5(5〜7才))を対象に基礎的な検討をした。すなわち，約5500Bq/m3のラドンを1回30分で隔日に30日間(計15回)それぞれ吸入させた。その結果，イヌにおいて，中性脂肪が減少する可能性が示された。また，その効果は吸入開始20〜30日後に現れることも示唆できた。他方，ネコにおいて，飲水量が改善し血清中クレアチニンが基準値内に減少する症例がみられるなど，慢性腎不全症に対し一定の効果が期待できる可能性が示唆された。
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=片岡隆浩
kn-aut-sei=片岡
kn-aut-mei=隆浩
aut-affil-num=1
ORCID=
en-aut-name=TokunagaRikizo
en-aut-sei=Tokunaga
en-aut-mei=Rikizo
kn-aut-name=徳永力三
kn-aut-sei=徳永
kn-aut-mei=力三
aut-affil-num=2
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=3
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=4
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=2
en-affil=
kn-affil=南富士ケンネル附属動物病院
affil-num=3
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科
en-keyword=dog
kn-keyword=dog
en-keyword=cat
kn-keyword=cat
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=serum biochemistry
kn-keyword=serum biochemistry
en-keyword=chronic renal failure
kn-keyword=chronic renal failure
END
start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=4
article-no=
start-page=241
end-page=251
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080425
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device
kn-title=ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究
en-subtitle=
kn-subtitle=
en-abstract=There are a lot of life style diseases that are related to reactive oxygen species in indications of the radon therapy, and, the further clarification of mechanism is expected. Therefore, in this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. It was enable that this device was the adjustments of radon concentration by changing the air flow rate to the specially processed radon source and so on. The mice were made to inhale the radon of 400Bq/m3 or 4000Bq/m3 with this device. Results show that in brain, lungs, liver, and kidney, both the activities of superoxide dismutase(SOD) and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.
kn-abstract=ラドン療法の適応症には活性酸素に由来する生活習慣病が多く，その機構の更なる解明が期待されている。また，汎用性があり医学的効果が再現できるラドン吸入装置の構築は意義が大きい。このため，著者らは共同で開発したラドン吸入試作装置を用い，マウス諸臓器中の抗酸化機能の変化特性を検討した。ラドン吸入試作装置は，特殊加工したラドン線源を収納したユニットの数量，それへの送風量及び湿度などを調節することによりラドン濃度を自在に調整可能にするものである。この装置によりマウスに400Bq/m3あるいは4000Bq/m3のラドンを吸入させた。その結果，脳・肺・肝臓・腎臓において，抗酸化系酵素であるSODとカタラーゼの両活性が増加し，過酸化脂質量が減少した。この抗酸化機能の亢進により，本実験条件でのラドン吸入は活性酸素障害の抑制，すなわち，生活習慣病の予防や症状緩和に効果のある可能性が改めて示唆できた。
en-copyright=
kn-copyright=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=中川慎也
kn-aut-sei=中川
kn-aut-mei=慎也
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=片岡隆浩
kn-aut-sei=片岡
kn-aut-mei=隆浩
aut-affil-num=2
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=3
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=石森有
kn-aut-sei=石森
kn-aut-mei=有
aut-affil-num=4
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=2
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=3
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=4
en-affil=
kn-affil=独立行政法人 日本原子力研究開発機構人形峠環境技術センター
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科
en-keyword=new radon exposure device
kn-keyword=new radon exposure device
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=antioxidative function
kn-keyword=antioxidative function
en-keyword=superoxide dismutase
kn-keyword=superoxide dismutase
en-keyword=catalase
kn-keyword=catalase
en-keyword=lipid peroxide
kn-keyword=lipid peroxide
en-keyword=active oxygen
kn-keyword=active oxygen
en-keyword=mouse
kn-keyword=mouse
en-keyword=radon-222
kn-keyword=radon-222
END
start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=5
article-no=
start-page=231
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120529
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl4)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m3 for 6hrs before or after CCl4 administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl4. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl4. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl4-induced oxidative damage in the brain, heart, lung, liver, and kidney.
en-copyright=
kn-copyright=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TeraokaJunichi
en-aut-sei=Teraoka
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=5
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=carbon tetrachloride
kn-keyword=carbon tetrachloride
en-keyword=oxidative damage
kn-keyword=oxidative damage
en-keyword=pre or post radon inhalation
kn-keyword=pre or post radon inhalation
en-keyword=antioxidative function
kn-keyword=antioxidative function
END
start-ver=1.4
cd-journal=joma
no-vol=146
cd-vols=
no-issue=1-3
article-no=
start-page=360
end-page=363
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201107
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Sakakibara Heart Institute of Okayama
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=11
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=12
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=2
article-no=
start-page=219
end-page=226
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MizuguchiYuko
en-aut-sei=Mizuguchi
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=organ transplantation
kn-keyword=organ transplantation
en-keyword=low-dose irradiation
kn-keyword=low-dose irradiation
en-keyword=antioxidative function
kn-keyword=antioxidative function
en-keyword=hepatopathy
kn-keyword=hepatopathy
END
start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200807
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.
en-copyright=
kn-copyright=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MizuguchiYuko
en-aut-sei=Mizuguchi
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=WangDa-Hong
en-aut-sei=Wang
en-aut-mei=Da-Hong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry
affil-num=7
en-affil=
kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=acatalasemic mouse
kn-keyword=acatalasemic mouse
en-keyword=radiosensitivity
kn-keyword=radiosensitivity
en-keyword=catalase
kn-keyword=catalase
en-keyword=glutathione peroxidase
kn-keyword=glutathione peroxidase
en-keyword=total glutathione
kn-keyword=total glutathione
END
start-ver=1.4
cd-journal=joma
no-vol=2012
cd-vols=
no-issue=
article-no=
start-page=11
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or γ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl4) hepatopathy. Moreover, radon inhalation also inhibits CCl4-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=6
article-no=
start-page=505
end-page=513
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20071121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Prior Low-dose X-irradiation on Ischemia-reperfusion Injury in Mouse Paw
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MizuguchiYuko
en-aut-sei=Mizuguchi
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=Edema
kn-keyword=Edema
en-keyword=Ischemia-reperfusion injury
kn-keyword=Ischemia-reperfusion injury
en-keyword=Low-dose irradiation
kn-keyword=Low-dose irradiation
en-keyword=Reactive oxygen species
kn-keyword=Reactive oxygen species
en-keyword=Antioxidation function
kn-keyword=Antioxidation function
END
start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KojimaShuji
en-aut-sei=Kojima
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ShibakuraMisako
en-aut-sei=Shibakura
en-aut-mei=Misako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=2
en-affil=
kn-affil=Misasa Medical Center, Okayama University Medical School
affil-num=3
en-affil=
kn-affil=Faculty of Pharmaceutical Sciences, Science University of Tokyo
affil-num=4
en-affil=
kn-affil=Departments of Medical Technology, Okayama University Medical School
affil-num=5
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=6
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=7
en-affil=
kn-affil=Misasa Medical Center, Okayama University Medical School
en-keyword=Radon hot spring
kn-keyword=Radon hot spring
en-keyword=Misasa
kn-keyword=Misasa
en-keyword=Cancer-related mortality rate
kn-keyword=Cancer-related mortality rate
en-keyword=p53 protein level
kn-keyword=p53 protein level
en-keyword=Superoxide dismutase activity
kn-keyword=Superoxide dismutase activity
END
start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Prior Low-dose X-ray Irradiation on Carbon Tetrachloride-induced Hepatopathy in Acatalasemic Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WangDa-Hong
en-aut-sei=Wang
en-aut-mei=Da-Hong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MoriShuji
en-aut-sei=Mori
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KiraShohei
en-aut-sei=Kira
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=2
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=3
en-affil=
kn-affil=Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry
affil-num=4
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=5
en-affil=
kn-affil=Public Health, Okayama University Medical School
affil-num=6
en-affil=
kn-affil=Pharmacology, Okayama University Medical School
affil-num=7
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=8
en-affil=
kn-affil=Public Health, Okayama University Medical School
en-keyword=Acatalasemic mouse
kn-keyword=Acatalasemic mouse
en-keyword=Catalase
kn-keyword=Catalase
en-keyword=CCl4
kn-keyword=CCl4
en-keyword=Hepatotoxicity
kn-keyword=Hepatotoxicity
en-keyword=Low-dose X-irradiation
kn-keyword=Low-dose X-irradiation
en-keyword=Antioxidant substances
kn-keyword=Antioxidant substances
END
start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=6
article-no=
start-page=775
end-page=781
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111122
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We examined dose?dependent or dose rate?dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day?Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose?rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=7
en-affil=
kn-affil=Misasa Medical Center, Okayama University Hospital
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=Radon
kn-keyword=Radon
en-keyword=Superoxide dismutase
kn-keyword=Superoxide dismutase
en-keyword=Dose
kn-keyword=Dose
en-keyword=Dose rate
kn-keyword=Dose rate
en-keyword=Large-scale facility
kn-keyword=Large-scale facility
END
start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=2
article-no=
start-page=713
end-page=722
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TeraokaJunichi
en-aut-sei=Teraoka
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MondenMayuko
en-aut-sei=Monden
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
affil-num=7
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=8
en-affil=
kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=inflammation
kn-keyword=inflammation
en-keyword=carrageenan
kn-keyword=carrageenan
en-keyword=edema
kn-keyword=edema
en-keyword=antioxidative function
kn-keyword=antioxidative function
END
start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=6
article-no=
start-page=559
end-page=567
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=AoyamaYutaka
en-aut-sei=Aoyama
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center
affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=ascorbic acid
kn-keyword=ascorbic acid
en-keyword=carbon tetrachloride
kn-keyword=carbon tetrachloride
en-keyword=antioxidative function
kn-keyword=antioxidative function
en-keyword=liver
kn-keyword=liver
END
start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
en-copyright=
kn-copyright=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=cold injury
kn-keyword=cold injury
en-keyword=brain edema
kn-keyword=brain edema
en-keyword=0.5 Gy irradiation
kn-keyword=0.5 Gy irradiation
en-keyword=antioxidative function
kn-keyword=antioxidative function
END
start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=2
article-no=
start-page=91
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Assessment of Radioactivity Levels of 210Pb and 40K in Tobacco and Radiation Exposure from Smoking
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Department of Radiation Research Shikata Laboratory, Advanced Science Research Center, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=tobacco
kn-keyword=tobacco
en-keyword=radionuclides
kn-keyword=radionuclides
en-keyword=smoking
kn-keyword=smoking
en-keyword=intake
kn-keyword=intake
en-keyword=radiation exposure
kn-keyword=radiation exposure
END
start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=648
end-page=652
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200805
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the Ra-226 activity concentrations.
en-copyright=
kn-copyright=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=IshimoriYu
en-aut-sei=Ishimori
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radioactivity
kn-keyword=radioactivity
en-keyword=radon emanation fraction
kn-keyword=radon emanation fraction
en-keyword=granite
kn-keyword=granite
en-keyword=Misasa
kn-keyword=Misasa
en-keyword=Badgastein
kn-keyword=Badgastein
END
start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=106
end-page=110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080623
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of some physical conditions on leaching rate of radon from radioactive minerals originating from some hot springs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to determine the best physical conditions for leaching more radon from minerals into water, we measured the leaching rate of radon from radioactive minerals under the conditions of some different grain sizes and water temperatures. Water temperature affected the leaching rate of radon although the grain size did not significantly affect it. Furthermore, we proposed ultrasonic irradiation to the mixture of a mineral and water as the method of leaching more radon. Ultrasonic irradiation was efficient to leach more radon from the mineral soaked in water because of ultrasonic cavitation.
en-copyright=
kn-copyright=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radon hot spring
kn-keyword=radon hot spring
en-keyword=radioactive mineral
kn-keyword=radioactive mineral
en-keyword=leaching
kn-keyword=leaching
en-keyword=grain size
kn-keyword=grain size
en-keyword=water temperature
kn-keyword=water temperature
en-keyword=ultrasonic irradiation
kn-keyword=ultrasonic irradiation
END
start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=27
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20011225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Attempts to create the amenity from the nursing point of view - Through approach by using the wrapping skills -
kn-title=看護の視点からのアメニティ創出への試み ―ラッピング技法を用いてのアプローチから―
en-subtitle=
kn-subtitle=
en-abstract=The importance of producing the comfortable environment, namely to create the amenity for the patients admitted in the hospitals, has been recognized recently. In this study, to create the better amenity for admitted patients' daily life by the nurses, we examined the influence of the ways of displaying, placing and decorating the daily materials, such as booklets, tea cups, letters and etc. on a bed side table, using the wrapping skills. As a result, we found out that creating the amenity using the wrapping skills might be useful for the admitted patients' care and their mental healing. Furthermore, we indicated some important points when using the wrapping skills, such as selecting appropriate materials and methods suiting for each subjected matter.
kn-abstract=病院におけるアメニティの重要性は十数年前から言われているが,それは建物の建築の時だけでなく,その後療養の場所をどのように維持し,快適環境を患者にいつまでも提供していくかである｡これまで日常の看護業務において掲示物やパンフレットの置き方,床頭台のあり方などは整理整頓の一環で病棟管理の中にあった｡だが,もう一つの流れがある｡ウイリアム・モリスは生活の中における芸術化を考え,生活用品そのものに美しきと手作りの良さがあることを提唱した｡こうした生活デザインの流れの中で,本研究では本学科棟内において床頭台のディスプレイや掲示の仕方,パンフレットの置き方など,ラッピング技法を使用し,入院生活上のアメニティの創出を試みた｡その後,ラッピング技法を用いたアメニティ創出の試みは患者の心を癒す可能性のあることを明らかにした｡また,ラッピング技法使用上の留意点についても指摘した｡
en-copyright=
kn-copyright=
en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=
en-aut-name=HayashiYuko
en-aut-sei=Hayashi
en-aut-mei=Yuko
kn-aut-name=林優子
kn-aut-sei=林
kn-aut-mei=優子
aut-affil-num=2
ORCID=
en-aut-name=OhiNobuko
en-aut-sei=Ohi
en-aut-mei=Nobuko
kn-aut-name=大井伸子
kn-aut-sei=大井
kn-aut-mei=伸子
aut-affil-num=3
ORCID=
en-aut-name=OkudaHiroyuki
en-aut-sei=Okuda
en-aut-mei=Hiroyuki
kn-aut-name=奥田博之
kn-aut-sei=奥田
kn-aut-mei=博之
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
affil-num=3
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
affil-num=4
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
affil-num=5
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=アメニティ (amenity)
kn-keyword=アメニティ (amenity)
en-keyword=ラッピング (wrapping skill)
kn-keyword=ラッピング (wrapping skill)
en-keyword=入院生活 (life in hospital)
kn-keyword=入院生活 (life in hospital)
en-keyword=色彩 (color)
kn-keyword=色彩 (color)
en-keyword=癒し (care healing)
kn-keyword=癒し (care healing)
END
start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=7
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20011225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recent medical studies on radon therapy in Europe
kn-title=欧州におけるラドン療法の医学的研究に関する最近の動向
en-subtitle=
kn-subtitle=
en-abstract=To elucidate the mechanism of radon therapy in Misasa radon spa, the author researched these recent studies in Europe. Parts of the results were as follows. In spas and galleries with a slightly elevated radon activity, the empirical medicine showed the same indications in the world. It mainly includes the more painful rheumatic diseases such as deformation or degeneration of the joints and non bacterial inflammation of muscles, tendons or joints ; Morbus Bechterew and other diseases of the vertebral column like spondylarthrosis or osteochondrosis. While these effects were seldom documented in an objecive manner formly, in recent years several prospective randomized double-blind studies proved the pain reducing efficacy of radon therapy in patients with cervical pain syndromes, with chronic polyarthritis or with Morbus Bechterew. Studies in experimental animal models have accumulated remarkable data in cultured cells, organs and tissue that provide a rationale to explain the observed effects of radon therapy in patients.
kn-abstract=本総説は,本邦で実施している三朝ラドン温泉の適応症に関する機構解明に資するために調査した欧州におけるラドン療法の医学的研究に関する最近の動向の概要についてまとめたものである｡すなわち,ラドンを用いた温泉や坑道での療法の適応症には,脊椎の非細菌性炎症(べヒテレフ病),慢性多発性関節炎,気管支喘息などが含まれる｡臨床医学的研究として,以前,客観的方法で検討されたものはほとんどなかったが,最近,無作為化二重盲検臨床試験などにより,ラドン療法がベヒテレフ病,慢性多発性関節炎などの患者の痛みを緩和させる効能があることが実証されつつある｡また,基礎医学的研究として,抗酸化機能や免疫機能などの指標に着目した動物実験により,ラドン療法の機構を解明する上で合理的根拠が得られつつあることもわかった｡さらに,これらの知見と本邦での研究動向を踏まえ,今後,期待されるラドン療法の機構解明を行うための研究課題を提案した｡
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
en-aut-name=MifuneTakashi
en-aut-sei=Mifune
en-aut-mei=Takashi
kn-aut-name=御舩尚志
kn-aut-sei=御舩
kn-aut-mei=尚志
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院
en-keyword=ラドン療法 (radon therapy)
kn-keyword=ラドン療法 (radon therapy)
en-keyword=適応症 (indication）
kn-keyword=適応症 (indication）
en-keyword=活性酸素 (active oxygen)
kn-keyword=活性酸素 (active oxygen)
en-keyword=二重盲検試験 (prospective randomized double-blind study)
kn-keyword=二重盲検試験 (prospective randomized double-blind study)
en-keyword=バードガスタイン (Badgastein)
kn-keyword=バードガスタイン (Badgastein)
END
start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=7
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20021225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recent trend of research on the adaptive response induced by low dose radiation and its significance
kn-title=低線量放射線の適応応答に関する最近の研究動向とその意義
en-subtitle=
kn-subtitle=
en-abstract=We reviewed the recent trend of research on the adaptive response induced by low dose radiation and its significance. The following view were obtained. Risk assessment is fundamental to the protection of public health from radiation exposure, but any estimate of risk is subject to numerous major uncertainties. In view of the uncertainties surrounding the shape of dose-response curves at low doses of ionizing radiation. the linear nonthreshold dose-response model is now widely accepted as a paradigm in radiation protection practice and risk analysis. However, interest among scientists in obtaining a more conclusive understanding of the effects of low dose radiation has been evident in recent initiatives, such as adaptive response of low dose radiation, in part to help verify or disprove the linear model. A vigorous worldwide effort is now apparently underway to understand the basic mechanisms underlying the biological effects of low dose radiation. This review presents a series of papers representing the progress going on, which will undoubtably make an important contribution to this field of research.
kn-abstract=本総説は,低線量放射線に対する生体の適応応答(以下,適応応答)に関してその効果を含む最近の研究動向,さらに放射線防護との関係についてまとめたものである｡特にこの分野で最も検討が進んでいる｢低線量放射線照射の生物学的影響｣に関する国際研究組織(BELLE)での動向を中心に報告するものである｡即ち,ヒトと自然放射線との共存などヒトの生活環境と適応応答について,適応応答の短期的･長期的効果など適応応答の効果とその生物学的意義について言及した｡次に,適応応答の医療などへの応用の可能性について,また,適応応答と放射線防護との関係についても言及した｡ここで,低線量放射線にはヒトへの有益な効果があるとの多くの報告例がある半面,放射線防護の面では微量放射線でも危険とする考え方がその根拠にあることがわかった｡このため,今後は更なる低線量放射線の生体影響研究を進めるとともに,両者の間の隙間をなくす現実的･合理的な対応が求められている｡
en-copyright=
kn-copyright=
en-aut-name=KusuharaToshimasa
en-aut-sei=Kusuhara
en-aut-mei=Toshimasa
kn-aut-name=楠原俊昌
kn-aut-sei=楠原
kn-aut-mei=俊昌
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=低線量放射線 (low dose radiation)
kn-keyword=低線量放射線 (low dose radiation)
en-keyword=低濃度化学物質 (low dose chemicals)
kn-keyword=低濃度化学物質 (low dose chemicals)
en-keyword=適応応答 (adaptive response)
kn-keyword=適応応答 (adaptive response)
en-keyword=放射線ホルミシス (radiation hormesis)
kn-keyword=放射線ホルミシス (radiation hormesis)
en-keyword=放射線防護 (radiation protection)
kn-keyword=放射線防護 (radiation protection)
END
start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis
kn-title=化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向
en-subtitle=
kn-subtitle=
en-abstract=To elucidate the health effects by low dose radiation, we reviewed the recent trend of research on the epigenetic mechanisms of chemical carcinogenesis. The following view were obtained. It has become apparent that chemical and physical agents that induce cancer may do so through different cellular and molecular mechanisms. Investigators, recognizing the apparent differences in the ways compounds
participate in the carcinogenesis process, coined the phrases "genotoxic" and "epigenetic" in describing activities of chemicals and physical agents that induced
cancer. The term "nongenotoxic" has to some extent replaced "epigenetic" and thus, classification of chemical carcinogens has been frequently delegated to either the genotoxic or nongenotoxic categories. Moreover, while much work remains in the understanding of the modes and mechanisms of action of nongenotoxic carcinogens and the epigenetic effects of these agents, it is apparent that this category of chemicals are functionally different than those compounds which directly interact, mutate, and modify genomic DNA.
kn-abstract=本総説は,筆者らが進めている｢低線量放射線の健康への影響と医療への応用｣に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである｡即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した｡また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた｡その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ
れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった｡また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=
en-aut-name=InaYasuhiro
en-aut-sei=Ina
en-aut-mei=Yasuhiro
kn-aut-name=稲恭宏
kn-aut-sei=稲
kn-aut-mei=恭宏
aut-affil-num=3
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=片岡隆浩
kn-aut-sei=片岡
kn-aut-mei=隆浩
aut-affil-num=4
ORCID=
en-aut-name=KawabeAtsusi
en-aut-sei=Kawabe
en-aut-mei=Atsusi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=5
ORCID=
en-aut-name=SanoMasanobu
en-aut-sei=Sano
en-aut-mei=Masanobu
kn-aut-name=佐野正展
kn-aut-sei=佐野
kn-aut-mei=正展
aut-affil-num=6
ORCID=
en-aut-name=UjifukuAyako
en-aut-sei=Ujifuku
en-aut-mei=Ayako
kn-aut-name=氏福亜矢子
kn-aut-sei=氏福
kn-aut-mei=亜矢子
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=電力中央研究所低線量放射線研究センター
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=7
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
en-keyword=化学発がん (chemical carcinogenesis)
kn-keyword=化学発がん (chemical carcinogenesis)
en-keyword=非遺伝毒性 (nongenotoxicity)
kn-keyword=非遺伝毒性 (nongenotoxicity)
en-keyword=後成説 (epigenesis)
kn-keyword=後成説 (epigenesis)
en-keyword=酸化的ストレス (oxidative stress)
kn-keyword=酸化的ストレス (oxidative stress)
en-keyword=ギャップ結合 (gap junction)
kn-keyword=ギャップ結合 (gap junction)
END
start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=
article-no=
start-page=61
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20041201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy for patients with respiratory disease. Clinical efficacy and action mechanisms of the therapy on asthma
kn-title=呼吸器疾患に対する温泉療法 ―その臨床効果と作用機序―
en-subtitle=
kn-subtitle=
en-abstract=Spa therapy which has been performed for patients with respiratory disease, particularly for those with asthma and pulmonary emphysema for last 22 years demonstrates that spa therapy is effective for asthma and pulmonary emphysema.
The characteristics of patients with respiratory disease has been changing during last 22 years : the frequency of patients with steroid-dependent intractable asthma (SDIA) tends to decrease inspite of an increase in number of those with asthma who has been admitted at Misasa Medical
Center for spa therapy.
The frequency and number of patients with pulmonary emphysema has been increasing in recent years. Spa therapy has direct action mechanism for airways such as improvement
of subjective and objective symptoms, and improvement
of ventilatory function, bronchial hyperresponsiveness, and hyperinflation of the lungs. The therapy has also indirect action mechanism for other organs excluding the airways
such as improvement of suppressed function of adrenocortical glands, psychological relaxation, and an increase in SOD activity. These indirect actions of spa therapy play an important role in treatment of the disease.
kn-abstract=呼吸器疾患に対する温泉療法は,最近の22年間にわたり行われてきた結果,その有用性は十分明かとなっている｡この22年の間に,温泉療法を受ける対象もかなり変わってきており,例えば気管支喘息では,ステロイド依存性重症難治性喘息の全症例に対する割合は明
らかに低くなってきている｡また,COPDでは最近全症例に対する肺気腫の割合も,また症例数も著明に増加しつつある｡一方,温泉療法を求めて来院される症例数は年ごとに増加する傾向にあり,初期の5年間と比べ,最近の5年間では,気管支喘息では8.2倍,また肺気腫では
34.8倍の増加が観察されている｡呼吸器疾患に対する温泉療法の作用機序としては,直接作用として,自･他覚症状の改善,換気機能の改善,気道過敏性の改善,気道抵抗の低下,肺の過膨脹の改善,過分泌の抑制などが観察される｡一方,間接作用としては,副腎皮質機能の改善,精神的リラックス,抗酸化酵素であるSOD活性の克進などが観察され,これらの間接作用も気管支喘息の病態改善に重要な役割を果しているものと考えられる｡
en-copyright=
kn-copyright=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=
en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=
en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=
en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=濱田全紀
kn-aut-sei=濱田
kn-aut-mei=全紀
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=5
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=2
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=3
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=4
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=5
en-affil=
kn-affil=2)医学部保健学科医用放射線科
affil-num=6
en-affil=
kn-affil=2)医学部保健学科医用放射線科
en-keyword=温泉療法 (spa therapy)
kn-keyword=温泉療法 (spa therapy)
en-keyword=気管支喘息 (asthma)
kn-keyword=気管支喘息 (asthma)
en-keyword=精神的リラックス (psychological relaxation)
kn-keyword=精神的リラックス (psychological relaxation)
en-keyword=SOD活性 (SOD activity)
kn-keyword=SOD活性 (SOD activity)
en-keyword=副腎皮質機能
kn-keyword=副腎皮質機能
END
start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=11
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=200512
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study on the effects of the archeological investigation and the construction work
on the environmental radiation
kn-title=埋蔵文化財発掘調査および建設工事が環境放射線に及ぼす影響に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we investigated how the excavation of ruins and the construction work affected the environmental radiation in the Shikata campus of Okayama University (S-campus). The environmental radiation was steady in the S-campus until 1997, but began to change since 1998, while the ruin's survey and the construction work started frequently after 1998 in the S-campus. In general, the soil and the concrete include the natural radioisotope (uranium series and thorium series, etc). When ruins are surveyed, it is necessary to move a large amount of the soil. In addition, a large amount of the concrete is used for the construction work. To measure the environmental radiation, the monitor posts were set up on the east and west sides of the building of the Radioisotope Center (RIC). We sampled the soil in the container in each place. We used the high-purity germanium detector to analyze them. The monitor posts showed the difference in the in-air dose rate in each place in the S-campus. The in-air dose rate at the east side of the RIC was higher than that at the west side. The result of analysis showed that the soil includes the (40)K at the east side. While the specific activity of the 40K was 0.849Bq/g at the east side, the (40)K was hardly detected in the soil at the west side. The each soil included the 214-lead and 214-bismus ((214)Pb, (214)Bi), however, there was no significant difference in the specific activity of the each soil. The concrete included (40)K, whose specific activity was 0.492Bq/g. It was suggested that the change of the environmental radiation was attributed to radon and its daughter nuclides in the soil rather than the radiation from the concrete in the buildings.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=3
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター
affil-num=2
en-affil=
kn-affil=岡山大学医学部
affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター
affil-num=4
en-affil=
kn-affil=岡山大学医学部
en-keyword=archeological investigation
kn-keyword=archeological investigation
en-keyword=construction work
kn-keyword=construction work
en-keyword=environmental radiation
kn-keyword=environmental radiation
en-keyword=soil
kn-keyword=soil
en-keyword=concrete
kn-keyword=concrete
END
start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=
article-no=
start-page=33
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学における核燃料物質の安全管理のための劣化ウランと天然ウランの鑑別について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In Japan, the Law for the Regulation of Nuclear Source Materials, Nuclear Fuel Materials and Reactors (Regulation Law) controls the nuclear fuel materials such as thorium (Th), uranium (U) and plutonium (Pu). Under the Regulation Law, all related materials and reactors are needed to register to the Government. In Okayama University, many nuclear fuel materials, mainly uranium compounds, are registered and stored in 11 departments, separately. Discrimination between depleted uranium and natural uranium is important for the observance of the Regulation Law and the safety management of the nuclear fuel materials in the Okayama University. However, the discrimination of the two kind of uranium has poorly analyzed. In this study, we analyzed several uranium compounds by using γ-ray spectrometry to determine whether the depleted uranium or not.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=花房直志
kn-aut-sei=花房
kn-aut-mei=直志
aut-affil-num=2
ORCID=
en-aut-name=KinnoIkuo
en-aut-sei=Kinno
en-aut-mei=Ikuo
kn-aut-name=金野郁雄
kn-aut-sei=金野
kn-aut-mei=郁雄
aut-affil-num=3
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=4
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=2
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=7
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
en-keyword=Nuclear Fuel Materials
kn-keyword=Nuclear Fuel Materials
en-keyword=Depleted Uranium
kn-keyword=Depleted Uranium
en-keyword=Natural Uranium
kn-keyword=Natural Uranium
en-keyword=γ-ray Spectrometry
kn-keyword=γ-ray Spectrometry
END
start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19991220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Rationalization of measures to protect the working environment in radiation controlled areas from the perspective of the relationship between surface and airborne contamination
kn-title=放射線管理区域における作業環境測定の合理化の検討 ―表面汚染と空気汚染の関係に着目して―
en-subtitle=
kn-subtitle=
en-abstract=In radiation controlled areas, measures have been taken to assess the radiation dose to workers, but these efforts are limited due to high labor and cost factors in extremely low dose radiation controlled areas. And so they have been expected to be rationalized. Therefore, we first reviewed the present conditions of these working environment measurement and elucidated the relationship between surface and airborne contamination in radiation controlled areas. Second, we reviewed the qualities of several surface contamination measurements such as smear test and possibilities for their improvement. As a result, we developed some future programs for rationalization of the working environment measurements, for example, an algorithm for selecting the proper surface contamination measurement for each measurement area based on the conditions specific to that area.
kn-abstract=放射線管理区域において業務従事者の放射線防護が正確に実施されていることを確認するために放射性同位元素の環境測定が行われている。しかし，実際の測定においては，濃度が低いなど実測困難な場合が多いこと，多くの人手と経費を要していることから，より合理的な測定の実施ができないかということについての検討が期待されている。このため本総説では，まず大学などの放射線管理区域における作業環境測定方法の現状についてまとめた。次に，放射線管理区域の床，作業台などにおける放射性同位元素の表面汚染と空気汚染に着目し，汚染粒子の移行など表面汚染と空気汚染の関係機構について，また，スミア法や直接測定法などの各種表面汚染測定法の汚染採取効率などを指標とした特性とこれら測定法の改良の試みについてまとめた。さらに，実際の作業場所において，作業内容，換気，表面材料などが表面汚染と空気汚染の関係に及ぼす影響について，その検討例を紹介した。得られた知見をまとめるとともに，測定箇所・測定頻度の適性化やそれぞれの測定箇所に適した測定法の選定など作業環境測定の一層の合理化に向けて，今後どのような検討が必要なのかについて提案した。
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
en-aut-name=ShibuyaKoichi
en-aut-sei=Shibuya
en-aut-mei=Koichi
kn-aut-name=澁谷光一
kn-aut-sei=澁谷
kn-aut-mei=光一
aut-affil-num=2
ORCID=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=3
ORCID=
en-aut-name=KawasakiShoji
en-aut-sei=Kawasaki
en-aut-mei=Shoji
kn-aut-name=川ｱ祥二
kn-aut-sei=川ｱ
kn-aut-mei=祥二
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=岡山大学アイソトープ総合センター
affil-num=4
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=放射線管理区域 (radiation controlled area)
kn-keyword=放射線管理区域 (radiation controlled area)
en-keyword=作業環境測定 (working environment measurement)
kn-keyword=作業環境測定 (working environment measurement)
en-keyword=表面汚染測定法 (surface contamination measurement)
kn-keyword=表面汚染測定法 (surface contamination measurement)
en-keyword=スミア法 (smear test)
kn-keyword=スミア法 (smear test)
en-keyword=採取効率 (collecting efficiency)
kn-keyword=採取効率 (collecting efficiency)
END
start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20001116
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Approach on the simple and easy method for measurement of airborne radioactive iodine((125)I)
kn-title=放射性ヨウ素（(125)I）の空気中濃度測定の簡便化に向けての基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=Radioactive iodines (iodine-123, -125, -131) are used as the marker in vitro test, nuclear medicine and so on. It is necessary to handle them carefully, because radioactive iodines scatter easily. As air concentration limits of radioisotopes are very low levels, we should prepare the measurement technique using a large-volumed aspirator and large-scaled equipments. In this study, we examined the simple and easy method for the measurement of concentration of airborne radioactive iodines. We designed and manufactured the simple set of holder and charcoal filter connected to hypodermic syringe. The collecting efficiency of airborne iodine-125 by this system was 44.5%. In the case of that a liter of the air was filtered by this system connected to 50 m? syringe and counted the radioactivity for 30 minutes by the NaI(Tl) well-type
scintillation counter, It is indicated that iodine-125 of air concentration limit can be measured.
kn-abstract=放射性ヨウ素（(123)I，(125)I，(131)I）は飛散しやすいなどの特性があり，他の放射性核種に比べ慎重な取扱いが求められている。また，この核種の空気中濃度限度は非常に低く，濃度測定には大量の空気を吸引しなければならず，そのための装置も大掛かりとなる。このため，本研究では，活性炭ろ紙をホルダにセットし，これを注射器に取り付けた簡易な装置を考案・試作し，空気中の放射性ヨウ素濃度を簡便に測る方法について実験・検討した。その結果，まず放射性ヨウ素にNa(125)Iを用いた場合の捕集効率は44.5％であることが分かった。次に，50m?注射器を用いて1?の空気を吸引・ろ過し，Nal（Tl）ウェルタイプシンチレーションカウンタで30分間放射能を測定した場合，本装置では空気中濃度限度の2.12倍の濃度の(125)Iが測定可能であり，気体状ヨウ素の漏れを防いで捕集効率を94.3％以上に上げることができれば，空気中濃度限度まで測定可能であることが示された。このため，本法は簡便かつ安価に異常を検知する測定方法として利用できるのではないかと考えられた。
en-copyright=
kn-copyright=
en-aut-name=ShibuyaKoichi
en-aut-sei=Shibuya
en-aut-mei=Koichi
kn-aut-name=澁谷光一
kn-aut-sei=澁谷
kn-aut-mei=光一
aut-affil-num=1
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=2
ORCID=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=3
ORCID=
en-aut-name=KawasakiShoji
en-aut-sei=Kawasaki
en-aut-mei=Shoji
kn-aut-name=川崎祥二
kn-aut-sei=川崎
kn-aut-mei=祥二
aut-affil-num=4
ORCID=
en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
kn-aut-mei=祥夫
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=岡山大学アイソトープ総合センター
affil-num=4
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学講座
en-keyword=(125)I (radioactive iodine-125)
kn-keyword=(125)I (radioactive iodine-125)
en-keyword=空気中濃度限定 (air concentration limit)
kn-keyword=空気中濃度限定 (air concentration limit)
en-keyword=活性炭ろ紙 (charcoal filter)
kn-keyword=活性炭ろ紙 (charcoal filter)
END
start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20001116
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=低線量放射線による抗酸化系の誘導と活性酸素病治療への応用の可能性
kn-title=Induction of endogenous antioxidant system by low dose radiation and its applicable possibility for treatment of active oxygen species related diseases
en-subtitle=
kn-subtitle=
en-abstract=ストレスなどの原因により生体内に生じた過剰な活性酸素は毒性を有し，これが細胞や組織障害につながり，老化や発癌など種々の病的状態を生み出している。これに対し，生体には活性酸素を消去したり，損傷を起こした分子を修復したりして結果的に生ずる障害を防御する機構がある。この抗酸化系防御機構は適度な酸化ストレス，即ち少量の活性酸素を生体内に発生させる環境下では，逆に活性化する可能性があり，注目されている。本総説は，少量活性酸素を生体内に生じさせる低線量放射線による抗酸化系防御機構の活性化の有無，生体膜の構造変化と機能活性に及ぼす作用，活性酸素病などの遠因となる生体内酸化傷害に及ぼす作用，さらにはラドン（主にα線放出）療法の適応症の機構について，今までに実施した我々の研究例を中心に総括し，評価するものである。即ち，マウス，ラットへのX線γ線照射実験やラビットへのラドン吸入実験により得られた成果例は次の通りである。低線量のX線，γ線照射やラドン吸入により，高線量放射線の場合とは逆に，週齢や臓器などに放射線感受性に違いはあるものの過酸化脂質量が減少し，膜流動性やATPase活性が若齢値に近づくように変化した。SOD，Cat，GPXなどの酵素活性が誘導合成に伴い亢進した。また，低線量放射線照射によりI型糖尿病症状，鉄あるいは四塩化炭素の誘導による肝障害，MPTPの誘導による脳障害などが緩和された。さらに，ラドン吸入により組織循環の促進や疼痛の緩和などが明らかになった。これらの知見より，低線量放射線は抗酸化系防御機構を活性化するとともに生体膜機能の若返り化を導くことが示唆できた。また，低線量放射線は糖尿病I型症状や肝，脳障害を緩和することから，活性酸素病の治療応用への可能性も示唆できた。さらに，ラドン療法の適応症の代表例である疼痛緩和などについても機構解明の一端がなされた。
kn-abstract=We clarified that adequate oxygen stress induced by low dose radiation activates not only chemical biological protective function, such as induction of the synthesis of SOD, GPX and HSP70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose radiation can contribute to suppressing aging and to preventing or reducing active oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose radiation on the functions of the living body, including adaptive response.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=antioxidant system (抗酸化系)
kn-keyword=antioxidant system (抗酸化系)
en-keyword=low dose radiation (低線量放射線)
kn-keyword=low dose radiation (低線量放射線)
en-keyword=radon inhalation (ラドン)
kn-keyword=radon inhalation (ラドン)
en-keyword=active oxygen species related diseases (活性酸素病)
kn-keyword=active oxygen species related diseases (活性酸素病)
en-keyword=adaptive response (適応応答 )
kn-keyword=adaptive response (適応応答 )
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=低線量放射線が生体機能に及ぼす影響に関する研究) 第1編低線量X線照射によるラット諸臓器中のSOD活性の増加と過酸化脂質量の減少) 第2編低線量X線照射が老齢ラット大脳皮質の生体膜に及ぼす影響) 第3編ラドン吸入が生体機能に及ぼす影響 過酸化脂質量,SOD活性及び膜流動性
kn-title=Study on Effects of Low Dose Radiation on Biological Function 第1編 Increased SOD Activities and Decreased Lipid Peroxide Levels Induced by Low Dose X Irradiation in Rat Organs 第2編 Effects of Low Dose X-ray Irradiation on Biomembrane in Brain Cortex of Aged Rats 第3編 Effects of Radon Inhalation on Biological Function-Lipid Peroxide Level Superoxide Dismutase Activity and Membrane Fluidity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
END