ID | 57366 |
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フルテキストURL | |
著者 |
Wake, Hidenori
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
publons
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抄録 | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
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キーワード | htidine-rich glycoprotein
septic pathogenesis
immunothrombosis
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Amo Type | Review
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2019-10
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巻 | 73巻
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号 | 5号
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出版者 | Okayama University Medical School
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開始ページ | 379
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終了ページ | 382
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2019 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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