start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=11
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190605
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. 
en-copyright=
kn-copyright=

en-aut-name=WangNing
en-aut-sei=Wang
en-aut-mei=Ning
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=?witalskaMarta
en-aut-sei=?witalska
en-aut-mei=Marta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangLi 
en-aut-sei=Wang
en-aut-mei=Li 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShabanElkhabiry
en-aut-sei=Shaban
en-aut-mei=Elkhabiry
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HossainMd Imran
en-aut-sei=Hossain
en-aut-mei=Md Imran
kn-aut-name=  
kn-aut-sei=
kn-aut-mei=  
aut-affil-num=5
ORCID=

en-aut-name=El SayedIbrahim El Tantawy 
en-aut-sei=El Sayed
en-aut-mei=Ibrahim El Tantawy 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WietrzykJoanna
en-aut-sei=Wietrzyk
en-aut-mei=Joanna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InokuchiTsutomu
en-aut-sei=Inokuchi
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=8
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=cryptolepine
kn-keyword=cryptolepine
en-keyword=neocryptolepine
kn-keyword=neocryptolepine
en-keyword=isocryptolepine
kn-keyword=isocryptolepine
en-keyword=antiproliferative activity
kn-keyword=antiproliferative activity
en-keyword=structure activity relationships
kn-keyword=structure activity relationships
END