JaLCDOI | 10.18926/AMO/45266 |
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フルテキストURL | 65_2_81.pdf |
著者 | Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi| |
抄録 | Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease. |
キーワード | kidney inflammation chemokine |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-04 |
巻 | 65巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 81 |
終了ページ | 89 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21519365 |
Web of Science KeyUT | 000289818800003 |
JaLCDOI | 10.18926/AMO/52789 |
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フルテキストURL | 68_4_235.pdf |
著者 | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
抄録 | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
キーワード | microalbuminuria type 2 diabetes mellitus remission regression |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-08 |
巻 | 68巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 235 |
終了ページ | 241 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25145409 |
Web of Science KeyUT | 000340687500005 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
著者 | 片岡 仁美| |
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発行日 | 2012-04-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 124巻 |
号 | 1号 |
資料タイプ | 学術雑誌論文 |
タイトル(別表記) | Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages |
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フルテキストURL | 126_1.pdf |
著者 | 宮本 聡| 四方 賢一| 宮坂 京子| 岡田 震一| 佐々木 基史| 小寺 亮| 廣田 大昌| 梶谷 展生| 高塚 哲全| 片岡 仁美| 西下 伸吾| 堀口 千景| 船越 顕博| 西森 久和| 内田 治仁| 小川 大輔| 槇野 博史| |
キーワード | cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2014-04-01 |
巻 | 126巻 |
号 | 1号 |
開始ページ | 1 |
終了ページ | 6 |
ISSN | 0030-1558 |
関連URL | http://www.okayama-u.ac.jp/user/oma/ |
言語 | 日本語 |
著作権者 | Copyright (c) 2014 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.126.1 |
タイトル(別表記) | Okayama University Survey of the current situation of community-based medical facilities supported by part-time work by physicians |
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フルテキストURL | 127_13.pdf |
著者 | 勅使川 早苗| 岩瀬 敏秀| 金森 達也| 川畑 智子| 佐藤 勝| 片岡 仁美| |
抄録 | We investigated the situation of how physicians at Okayama University support local medical institutions by serving as a part-time worker, and analyzed the difference between the five medical districts of Okayama prefecture and other prefectures. Many physicians (actual number of physicians, full-time equivalent number of physicians) served in the southeastern region of the Okayama prefecture (339, 82.2). On the other hand, fewer physicians (42, 11.4) served in Takahashi・Niimi in the northwestern region of Okayama. Many physicians also served in Hiroshima prefecture (193, 48.8), Hyogo prefecture (109, 26.7), and the four prefectures of Shikoku Island (81, 23.6). It has been clarified that many physicians at Okayama University are working on a part-time basis to support local and community medical institutions in the wide area of Okayama prefecture, Hiroshima prefecture, Hyogo prefecture and the four prefectures of Shikoku Island. |
キーワード | 岡山大学勤務医師(physicians at Okayama University) 非常勤勤務(part-time worker) 地域医療機関支援(community-based medical facilities) |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2015-04-01 |
巻 | 127巻 |
号 | 1号 |
開始ページ | 13 |
終了ページ | 17 |
ISSN | 0030-1558 |
言語 | 日本語 |
著作権者 | Copyright (c) 2015 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.127.13 |
NAID | 130005068345 |