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ID 59939
フルテキストURL
著者
Tsunashima, Kenta Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Jinno, Katsuya Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Hiramatsu, Bunta Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Fujimoto, Kayo Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Sakai, Kenji Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Kaken ID
Kiwa, Toshihiko Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Kaken ID researchmap
Saari, Mohd Mawardi Faculty of Electrical & Electronic Engineering, Universiti Malaysia Pahang
Tsukada, Keiji Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Kaken ID researchmap
抄録
Manipulation of magnetic nanoparticles (MNP) by an external magnetic field has been widely studied in the fields of biotechnology and medicine for collecting and/or reacting biomaterials in the solutions. Here, dynamic behaviors of MNP in solution under changing gradient magnetic field were investigated using our newly developed laser transmission system (LTS) with a variable magnetic field manipulator. The manipulator consists of a moving permanent magnet placed beside the optical cell filled with MNP solution. A laser beam was focused on the cell and the transmitted laser beam was detected by a silicon photodiode, so that the localized concentration of the MNP at the focused area could be evaluated by the intensity of transmitted laser beam. In this study, the LTS was applied to evaluate dynamic behaviors of MNP in serum solution. Dispersion and aggregation of MNP in the solution were evaluated. While time evolution of dispersion depends on the serum concentration, the behavior during aggregation by the magnetic field was independent of the serum concentration. A series of measurements for zeta-potentials, distributions of particle size, and magnetization distributions was carried out to understand this difference in the behavior. The results indicated that a Brownian motion was main force to distribute the MNP in the solution; on the other hand, the magnetic force to the MNP mainly affected the behavior during aggregation of the MNP in the solution.
発行日
2020-01
出版物タイトル
AIP Advances
10巻
1号
出版者
AIP Publishing
ISSN
2158-3226
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© Author(s) 2020
論文のバージョン
publisher
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1063/1.5130167
ライセンス
http://creativecommons.org/licenses/by/4.0/
助成機関名
文部科学省
助成番号
JP15H05764