ID | 58236 |
フルテキストURL | |
著者 |
Suzuki, Yoko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
ORCID
Taniguchi, Kohei
Department of Pathological diagnosis, Okayama University Japan Hospital
Hatono, Minami
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Kajiwara, Yukiko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Abe, Yuko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Kawada, Kengo
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Tsukioki, Takahiro
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Kochi, Mariko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Nishiyama, Keiko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Iwamoto, Takayuki
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Kaken ID
researchmap
Ikeda, Hirokuni
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Shien, Tadahiko
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
ORCID
Kaken ID
publons
researchmap
Taira, Naruto
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
Kaken ID
publons
Tabata, Masahiro
Department of Hematology, Oncology, Respiratory, and Allergy Medicine, Okayama University Japan Hospital
Yanai, Hiroyuki
Department of Pathological diagnosis, Okayama University Japan Hospital
Doihara, Hiroyoshi
Department of Breast and Endocrine surgery in Okayama University Japan Hospital
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抄録 | Background Angiosarcoma of the breast is very rare and can be divided into primary and secondary angiosarcoma. Radiation-induced angiosarcoma (RIAS) is classified as secondary angiosarcoma. Diagnosis of RIAS is difficult due to its rarity, and the interpretation of pathological imaging is complicated. In the National Comprehensive Care Network (NCCN) guidelines, the first choice of treatment is surgery with negative margins. Adjuvant radiotherapy (RT) for close soft tissue margins should be considered. Preoperative or adjuvant chemotherapy of nonmetastatic disease is not recommended for angiosarcoma. We report a case of RIAS, which was impossible to diagnose with core needle biopsy (CNB) but was diagnosed by excisional biopsy. The patient was then administered adjuvant chemotherapy using conjugated paclitaxel (PTX).
Case presentation A 62-year-old woman noticed a tumor in her right breast. She had a history of right breast cancer and had undergone breast-conserving surgery, RT, and tamoxifen therapy 8 years previously. CNB, which was performed twice, was inconclusive. The tumor was surgically excised and pathological analysis yielded a diagnosis of angiosarcoma. She then underwent a right mastectomy. One month after she underwent right mastectomy, a nodule reappeared on the skin of her right breast, and excisional biopsy revealed recurrence of angiosarcoma. A few weeks later another nodule reappeared near the post-operative scar and excisional biopsy revealed recurrence of angiosarcoma. We assumed that surgical therapy was insufficient because the patient experienced relapse of angiosarcoma after complete mastectomy. After the second recurrence, we treated her with systemic chemotherapy using PTX. There was no evidence of recurrence 8 months after chemotherapy. Conclusion Although angiosarcoma is difficult to diagnose, many patients have a poor prognosis. Therefore, prompt treatment intervention is desired. Moreover, there is little evidence regarding adjuvant therapy of angiosarcoma since it is a rare disease. We consider that adjuvant therapy helped to effectively prevent recurrence in the patient after complete excision. |
キーワード | Radiation-induced angiosarcoma
Radiotherapy
Breast-conserving surgery
Breast cancer
Paclitaxel therapy
Adjuvant therapy of angiosarcoma
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発行日 | 2020-01-16
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出版物タイトル |
Surgical Case Reports
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巻 | 6巻
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号 | 1号
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出版者 | SpringerOpen
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開始ページ | 25
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ISSN | 2198-7793
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s). 2020
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1186/s40792-020-0790-7
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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