ID | 53635 |
フルテキストURL | |
著者 |
海老沼 孝至
岡山大学病院
Sato, Takamaro
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsunaga, Kazuyuki
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kudo, Chieko
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maeda, Hiroshi
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
前田 嘉信
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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谷本 光音
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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髙柴 正悟
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
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抄録 | [Purpose]
We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT.
[Methods]
Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 ± 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day −7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 ± 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa.
[Results]
Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days −7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days −7 to −1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA).
[Conclusions]
mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported.
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キーワード | Hematopoietic cell transplantation
Oral mucosa
Bacteria
mecA
Antibiotic-resistant
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備考 | The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-014-2151-1
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発行日 | 2014-06
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出版物タイトル |
Supportive Care in Cancer
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巻 | 22巻
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号 | 6号
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出版者 | Springer Berlin Heidelberg
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開始ページ | 1679
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終了ページ | 1683
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ISSN | 0941-4355
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NCID | AA10996793
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://link.springer.com/journal/520
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言語 |
英語
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著作権者 | Springer-Verlag Berlin Heidelberg
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論文のバージョン | author
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査読 |
有り
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DOI | |
PubMed ID | |
Web of Science KeyUT |