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ID 61215
JaLCDOI
フルテキストURL
74_6_545.pdf 2.12 MB
著者
Tatebe, Yasuhisa Department of Pharmacy, Okayama University Hospital
Kanamitsu, Kiichiro Department of pediatrics, Okayama University Hospital
Kanzaki, Hirotaka Department of Pharmacy, Okayama University Hospital
Ishida, Hisashi Department of pediatrics, Okayama University Hospital
Fujiwara, Kaori Department of pediatrics, Okayama University Hospital
Washio, Kana Department of pediatrics, Okayama University Hospital
Kitamura, Yoshihisa Department of Pharmacy, Okayama University Hospital ORCID Kaken ID publons researchmap
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital Kaken ID publons researchmap
Shimada, Akira Department of pediatrics, Okayama University Hospital ORCID Kaken ID researchmap
Tsukahara, Hirokazu Department of pediatrics, Okayama University Hospital Kaken ID publons researchmap
抄録
Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
キーワード
methotrexate
polymorphism
drug elimination
acute kidney injury
acute lymphoblastic leukemia
Amo Type
Case Report
出版物タイトル
Acta Medica Okayama
発行日
2020-12
74巻
6号
出版者
Okayama University Medical School
開始ページ
545
終了ページ
550
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
著作権者
CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT
NAID