ID | 61215 |
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著者 |
Tatebe, Yasuhisa
Department of Pharmacy, Okayama University Hospital
Kanamitsu, Kiichiro
Department of pediatrics, Okayama University Hospital
Kanzaki, Hirotaka
Department of Pharmacy, Okayama University Hospital
Ishida, Hisashi
Department of pediatrics, Okayama University Hospital
Fujiwara, Kaori
Department of pediatrics, Okayama University Hospital
Washio, Kana
Department of pediatrics, Okayama University Hospital
Kitamura, Yoshihisa
Department of Pharmacy, Okayama University Hospital
ORCID
Kaken ID
publons
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Tsukahara, Hirokazu
Department of pediatrics, Okayama University Hospital
Kaken ID
publons
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抄録 | Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
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キーワード | methotrexate
polymorphism
drug elimination
acute kidney injury
acute lymphoblastic leukemia
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Amo Type | Case Report
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2020-12
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巻 | 74巻
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号 | 6号
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出版者 | Okayama University Medical School
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開始ページ | 545
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終了ページ | 550
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2020 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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