start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=5 article-no= start-page=223 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=200210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Camptothecin induces urokinase-type plasminogen activator gene-expression in human RC-K8 malignant lymphoma and H69 small cell lung cancer cells. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We previously reported that anthracyclines, which could generate reactive oxygen species (ROS), could induce the urokinase-type plasminogen activator (uPA) gene expression in human RC-K8 malignant lymphoma cells and in H69 small cell lung cancer (SCLC) cells. In screening other uPA-inducible anti-cancer agents, we found that camptothecin (CPT) and its derivative, SN38, could induce uPA in RC-K8 and H69 cells. CPT and SN38, which are also used for the treatment of lymphoma and SCLC, significantly increased the uPA accumulation in the conditioned media of both cells in a dose-dependent manner. The maximum induction of uPA mRNA levels was observed 24 h after stimulation. Pretreatment with pyrrolidine dithiocarbamate (PDTC), an anti-oxidant, inhibited the CPT-induced uPA mRNA expression. Thus, CPT induces uPA through gene expression, and, therefore, CPT may influence the tumor-cell biology by up-regulating the uPA/plasmin system.

en-copyright= kn-copyright= en-aut-name=ShibakuraMisako en-aut-sei=Shibakura en-aut-mei=Misako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NiiyaKenji en-aut-sei=Niiya en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiguchiToru en-aut-sei=Kiguchi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=CPT kn-keyword=CPT en-keyword=SN38 kn-keyword=SN38 en-keyword=uPA kn-keyword=uPA en-keyword=RC-K8 kn-keyword=RC-K8 en-keyword=H69 kn-keyword=H69 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト肺小細胞癌細胞におけるドキソルビシンによるインターロイキン-8とモノサイトケモアトラクタントプロテイン-1の誘導 kn-title=INDUCTION OF IL-8 AND MONOCYTE CHEMOATTRACTANT PROTEIN-1 BY DOXORUBICIN IN HUMAN SMALL CELL LUNG CARCINOMA CELLS en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShibakuraMisako en-aut-sei=Shibakura en-aut-mei=Misako kn-aut-name=柴倉美砂子 kn-aut-sei=柴倉 kn-aut-mei=美砂子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=1 article-no= start-page=21 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur. en-copyright= kn-copyright= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KojimaShuji en-aut-sei=Kojima en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShibakuraMisako en-aut-sei=Shibakura en-aut-mei=Misako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=2 en-affil= kn-affil=Misasa Medical Center, Okayama University Medical School affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, Science University of Tokyo affil-num=4 en-affil= kn-affil=Departments of Medical Technology, Okayama University Medical School affil-num=5 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=6 en-affil= kn-affil=Departments of Radiological Technology, Okayama University Medical School affil-num=7 en-affil= kn-affil=Misasa Medical Center, Okayama University Medical School en-keyword=Radon hot spring kn-keyword=Radon hot spring en-keyword=Misasa kn-keyword=Misasa en-keyword=Cancer-related mortality rate kn-keyword=Cancer-related mortality rate en-keyword=p53 protein level kn-keyword=p53 protein level en-keyword=Superoxide dismutase activity kn-keyword=Superoxide dismutase activity END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=93 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beginning of International Exchange in the Faculty kn-title=国際交流に向けてのスタート en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukaiKiyoko en-aut-sei=Fukai en-aut-mei=Kiyoko kn-aut-name=深井喜代子 kn-aut-sei=深井 kn-aut-mei=喜代子 aut-affil-num=1 ORCID= en-aut-name=KatsudaToshizo en-aut-sei=Katsuda en-aut-mei=Toshizo kn-aut-name=勝田稔三 kn-aut-sei=勝田 kn-aut-mei=稔三 aut-affil-num=2 ORCID= en-aut-name=KondoMari en-aut-sei=Kondo en-aut-mei=Mari kn-aut-name=近藤麻理 kn-aut-sei=近藤 kn-aut-mei=麻理 aut-affil-num=3 ORCID= en-aut-name=ShibakuraMisako en-aut-sei=Shibakura en-aut-mei=Misako kn-aut-name=柴倉美砂子 kn-aut-sei=柴倉 kn-aut-mei=美砂子 aut-affil-num=4 ORCID= en-aut-name=AsariShoji en-aut-sei=Asari en-aut-mei=Shoji kn-aut-name=浅利正二 kn-aut-sei=浅利 kn-aut-mei=正二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=5 en-affil= kn-affil=岡山大学医学部保健学科 END