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ID 31560
JaLCDOI
フルテキストURL
著者
Imajo, Kenji Okayama University
Shinagawa, Katsuji Okayama University
Tada, Shinya Okayama Univerisity
Tsubota, Teruhiko Okayama University
Kimura, Ikuro Okayama University
抄録

The presence of the HTLV-I gene in peripheral blood mononuclear cells was studied by polymerase chain reaction in 42 patients including 16 with lung cancer, 12 with diffuse panbronchiolitis (DPB), 11 with idiopathic interstitial pneumonia (IIP), and 3 with pneumoconiosis and hematological malignancy. Sequences equal to a part of the pX gene were found in 44% of the lung cancer cases, 50% of the DPB cases, 55% of the IIP cases, and 100% of the cases of pneumoconiosis and leukemia. In the lung cancer cases, detection of the pX gene was frequently associated with the existence of diffuse interstitial pulmonary shadows. The pX gene was detected in 100% of patients with anti-HTLV-I antibody, 50% of patients with HTLV-I-related reaction and 14% of patients who tested seronegative. It may be inferred from the results that respiratory diseases that produce diffuse interstitial pulmonary shadows are closely associated with HTLV-I infection and that the HTLV-I-related reaction to the immunofluorescent test might reflect the latent infection state of HTLV-I.

キーワード
HTLV-1
polymerase chain reaction
HTLV-I associated bronchiolo-alveolar disorder
HTLV-I associated lung cancer
immunofluorescent assay
Amo Type
Article
発行日
1993-12
出版物タイトル
Acta Medica Okayama
47巻
6号
出版者
Okayama University Medical School
開始ページ
363
終了ページ
368
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT