start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=2
article-no=
start-page=171
end-page=175
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Severe Superimposed Preeclampsia with Obesity, Diabetes and a Mild Imbalance of Angiogenic Factors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity,
diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin
level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing
preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important
to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.
en-copyright=
kn-copyright=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NobumotoEtsuko
en-aut-sei=Nobumoto
en-aut-mei=Etsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SegawaTomonori
en-aut-sei=Segawa
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiramatsuYuji
en-aut-sei=Hiramatsu
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine

affil-num=2
en-affil=
kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine

affil-num=3
en-affil=
kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine

affil-num=4
en-affil=
kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
en-keyword=adipocytokine
kn-keyword=adipocytokine
en-keyword=angiogenic factor
kn-keyword=angiogenic factor
en-keyword=diet therapy
kn-keyword=diet therapy
en-keyword=obesity
kn-keyword=obesity
en-keyword=preeclampsia
kn-keyword=preeclampsia
END