start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=6
article-no=
start-page=293
end-page=297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199612
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Increased endothelial and epidermal thrombomodulin expression and plasma thrombomodulin level in progressive systemic sclerosis.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>To clarify the relation between systemic and cutaneous vascular endothelial injury in progressive systemic sclerosis (PSS), we examined thrombomodulin (TM) expression in PSS skin lesions immuno-histopathologically and compared it with plasma soluble TM levels measured by specific enzyme-linked immunosorbent assay. The plasma soluble TM level in PSS patients was significantly higher than that of normal controls and was as high as the levels of SLE patients. In relation to disease activities, the plasma TM levels of sclerotic phase PSS patients were significantly higher than that of atrophic phase PSS patients. The plasma samples with anti-Scl-70 antibody showed a high TM level than samples with anti-centromere antibody or anti-RNP antibody. Barnett's types or systemic corticosteroid treatment did not affect the TM level. Histopathologically, the dermal endothelial TM expression significantly increased in the sclerotic skin and moderately increased in the non-sclerotic skin of PSS compared with that of normal control skin. In addition, immunoreactive TM expression in the epidermis also increased in PSS. Disease activity-dependent elevation of plasma TM levels and immuno-histopathological expression of TM suggested generalized endothelial and epidermal cell involvement in PSS, and compensation in part by overproduction of TM by endothelial cells.</p>

en-copyright=
kn-copyright=

en-aut-name=MizutaniHitoshi
en-aut-sei=Mizutani
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayashiTatsuya
en-aut-sei=Hayashi
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NouchiNobuhiro
en-aut-sei=Nouchi
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InachiShin
en-aut-sei=Inachi
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiKoji
en-aut-sei=Suzuki
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShimizuMasayuki
en-aut-sei=Shimizu
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Mie University Faculty of Medicine

affil-num=2
en-affil=
kn-affil=Mie University Faculty of Medicine

affil-num=3
en-affil=
kn-affil=Mie University Faculty of Medicine

affil-num=4
en-affil=
kn-affil=Mie University Faculty of Medicine

affil-num=5
en-affil=
kn-affil=Mie University Faculty of Medicine

affil-num=6
en-affil=
kn-affil=Mie University Faculty of Medicine
en-keyword=thrombomodulin
kn-keyword=thrombomodulin
en-keyword=scleroderma
kn-keyword=scleroderma
en-keyword=skin
kn-keyword=skin
en-keyword=endothelial cells
kn-keyword=endothelial cells
en-keyword=keratinocyte
kn-keyword=keratinocyte
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=健常人における実験的冷刺激時の視床下部―脳下垂体―副腎系の反応動態ならびに口腔顔面部の疼痛閾値の変化
kn-title=Responses of the hypothalamic-pituitary-adrenal axis and pain threshold changes in the orofacial region upon cold pressor stimulation in normal volunteers.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SuzukiKoji
en-aut-sei=Suzuki
en-aut-mei=Koji
kn-aut-name=鈴木康司
kn-aut-sei=鈴木
kn-aut-mei=康司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END