ID | 59917 |
フルテキストURL | |
著者 |
Ohtsuki, Takashi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
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Hatipoglu, Omer F.
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Asano, Keiichi
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Inagaki, Junko
Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Nishida, Keiichiro
Department of Orthopaediac Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Hirohata, Satoshi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
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抄録 | In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1 beta (IL-1 beta) stimulation in chondrocytic cells. We also observed that ERK activation and NF-kappa B nuclear translocation were involved in the induction of CEMIP by IL-1 beta. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1 beta-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.
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キーワード | cell migration-inducing hyaluronidase 1 (CEMIP)
chondrocyte
hyaluronan
mechanical strain
nuclear factor kappa B (NF-kappa B)
osteoarthritis
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発行日 | 2020-04-29
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出版物タイトル |
International Journal of Molecular Sciences
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巻 | 21巻
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号 | 9号
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出版者 | MDPI
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開始ページ | 3140
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ISSN | 1422-0067
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/ijms21093140
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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助成機関名 |
日本学術振興会
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助成番号 | 17K19727
17H04313
19K09627
19K11791
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