Circulating aldosterone concentrations occasionally increase after initial suppression with angiotensin II (Ang II) converting enzyme inhibitors or Ang II type 1 receptor blockers (ARBs), a phenomenon referred to as aldosterone breakthrough. However, the underlying mechanism causing the aldosterone breakthrough remains unknown. Here we investigated whether aldosterone breakthrough occurs in human adrenocortical H295R cells in vitro. We recently reported that bone morphogenetic protein (BMP)-6, which is expressed in adrenocortical cells, enhances Ang II-but not potassium-induced aldosterone production in human adrenocortical cells. Accordingly, we examined the roles of BMP-6 in aldosterone breakthrough induced by long-term treatment with ARB. Ang II stimulated aldosterone production by adrenocortical cells. This Ang II stimulation was blocked by an ARB, candesartan. Interestingly, the candesartan effects on Ang II-induced aldosterone synthesis and CYP11B2 expression were attenuated in a course of candesartan treatment for 15 d. The impairment of candesartan effects on Ang II-induced aldosterone production was also observed in Ang II- or candesartanpretreated cells. Levels of Ang II type 1 receptor mRNA were not changed by chronic candesartan treatment. However, BMP-6 enhancement of Ang II- induced ERK1/2 signaling was resistant to candesartan. The BMP-6-induced Smad1, -5, and -8 phosphorylation, and BRE-Luc activity was augmented in the presence of Ang II and candesartan in the chronic phase. Chronic Ang II exposure decreased cellular expression levels of BMP-6 and its receptors activin receptor-like kinase-2 and activin type II receptor mRNAs. Cotreatment with candesartan reversed the inhibitory effects of Ang II on the expression levels of these mRNAs. The breakthrough phenomenon was attenuated by neutralization of endogenous BMP-6 and activin receptor-like kinase-2. Collectively, these data suggest that changes in BMP-6 availability and response may be involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.
en-copyright= kn-copyright= en-aut-name=OtaniHiroyuki en-aut-sei=Otani en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InagakiKenichi en-aut-sei=Inagaki en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiJiro en-aut-sei=Suzuki en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanoYoshihiro en-aut-sei=Kano en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GotoJunko en-aut-sei=Goto en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=ENZYME-INHIBITOR THERAPY kn-keyword=ENZYME-INHIBITOR THERAPY en-keyword=CHRONIC HEART-FAILURE kn-keyword=CHRONIC HEART-FAILURE en-keyword=CONVERTING ENZYME kn-keyword=CONVERTING ENZYME en-keyword=HYPERTENSIVE PATIENTS kn-keyword=HYPERTENSIVE PATIENTS en-keyword=PLASMA-ALDOSTERONE kn-keyword=PLASMA-ALDOSTERONE en-keyword=GRANULOSA-CELLS kn-keyword=GRANULOSA-CELLS en-keyword=SYSTEM kn-keyword=SYSTEM en-keyword=SECRETION kn-keyword=SECRETION en-keyword=NEPHROPATHY kn-keyword=NEPHROPATHY en-keyword=HYPERTROPHY kn-keyword=HYPERTROPHY END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=5 article-no= start-page=295 end-page=299 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of beta-adrenergic blocking agents on specific binding of [3H]D-Ala2-Met5-enkephalinamide and [3H]naloxone. en-subtitle= kn-subtitle= en-abstract= kn-abstract=To gain further insight into the central nervous system (CNS)-action of beta-adrenergic blocking agents (beta-blockers), we examined the effects of various kinds of beta-blockers on opioid receptors (Op-Rs) using radiolabeled receptor assay (RRA). We demonstrated that beta-blockers are competitively bound to Op-Rs in the CNS. Sodium index of beta-blockers in [3H]naloxone binding study indicated that beta-blockers had the mixed agonist-antagonist activity of opiates. The relative potency of beta-blockers in opioid RRA was negatively correlated with their membrane stabilizing activity. Neither beta-blocking activity nor intrinsic sympathomimetic activity was correlated with IC50 values of beta-blockers in opioid RRA. While it is widely accepted that beta-blockers have a tranquilizing activity, a part of the tranquilizing action of beta-blockers may be mediated through Op-Rs in the CNS. Although beta-blockers may have effects on their own receptors (beta-receptors) in the CNS, the more precise mechanisms of central action of these drugs must be further investigated.
en-copyright= kn-copyright= en-aut-name=TakayamaHaruhiko en-aut-sei=Takayama en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OgawaNorio en-aut-sei=Ogawa en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanumaMasato en-aut-sei=Asanuma en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HirataHiroshi en-aut-sei=Hirata en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=?-blocker kn-keyword=?-blocker en-keyword=opioid receptor kn-keyword=opioid receptor en-keyword=membrane stabilizing activity kn-keyword=membrane stabilizing activity en-keyword=sodium index kn-keyword=sodium index END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=5 article-no= start-page=269 end-page=276 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200111 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum total cholesterol of new students enrolled at Okayama University: trend during 1989-1998. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuuraKazuharu en-aut-sei=Matsuura en-aut-mei=Kazuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukiHisao en-aut-sei=Suzuki en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsukamotoChiaki en-aut-sei=Tsukamoto en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ImaiAyumi en-aut-sei=Imai en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TobeKazuo en-aut-sei=Tobe en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Health and Medical Center affil-num=2 en-affil= kn-affil=Health and Medical Center affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Health and Medical Center affil-num=5 en-affil= kn-affil=Health and Medical Center affil-num=6 en-affil= kn-affil=Health and Medical Center affil-num=7 en-affil= kn-affil=Health and Medical Center affil-num=8 en-affil= kn-affil=Health and Medical Center END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=149 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=200206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of change in body mass index on morbidity in non-obese university graduates. en-subtitle= kn-subtitle= en-abstract= kn-abstract=To establish the actual serial changes in body weight in Japanese people and to elucidate the influence of changes in BMI on morbidity, we conducted a historical cohort study of university graduates from 1955 to 1990 using questionnaires and BMI data. The subjects of this study were 3,675 university graduates aged 26-62 years in whom BMI was determined at the time of enrollment in the university (Pre-BMI), 5 to 40 years earlier. Morbidity (one or more system diseases or obesity-related system diseases) was analyzed according to current age, sex, current BMI, deltaBMI (difference between current BMI and pre-BMI), and various lifestyle variables. The proportion of overweight subjects at enrollment to university was higher in recent male students compared to old students, but not in female graduates, and the BMI in both genders increased progressively after graduation, especially in recent male graduates. Pre-BMI correlated negatively and significantly with deltaBMI. The percentages of obese (BMI > or = 30 kg/m2) males and females were 1.6% and 0.5%, respectively, and high morbidity was observed in 56.1% and 42.2% of males and females, respectively. Stepwise regression analysis showed that in subjects with normal BMI at enrollment, prospective morbidity was dependent on ABMI in addition to age. Our results indicate that in subjects with normal body weight, prospective morbidity is determined by increment of ABMI, and suggest that maintenance of BMI at the late adolescence level is an important factor in preventing future disease.
en-copyright= kn-copyright= en-aut-name=TobeKazuo en-aut-sei=Tobe en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsukamotoChiaki en-aut-sei=Tsukamoto en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InoueHajime en-aut-sei=Inoue en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ArataJiro en-aut-sei=Arata en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuuraKazuharu en-aut-sei=Matsuura en-aut-mei=Kazuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=body mass index kn-keyword=body mass index en-keyword=morbidity kn-keyword=morbidity en-keyword=overweight kn-keyword=overweight en-keyword=lifestyle-related diseases kn-keyword=lifestyle-related diseases en-keyword=masked obesity kn-keyword=masked obesity en-keyword=adolescent kn-keyword=adolescent END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=1 article-no= start-page=53 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhanced pressor response in spontaneously hypertensive rats induced by stimulation of vasopressin-V1 receptors. en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR.
en-copyright= kn-copyright= en-aut-name=YamauchiTakayoshi en-aut-sei=Yamauchi en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OishiTetsuya en-aut-sei=Oishi en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HaradaKazushi en-aut-sei=Harada en-aut-mei=Kazushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HashimotoMasami en-aut-sei=Hashimoto en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MimuraYukari en-aut-sei=Mimura en-aut-mei=Yukari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AsanoNaoko en-aut-sei=Asano en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univresity affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=vasopressin kn-keyword=vasopressin en-keyword=V1 and V2 receptor antagonist kn-keyword=V1 and V2 receptor antagonist en-keyword=hypertension kn-keyword=hypertension en-keyword=pressor response kn-keyword=pressor response en-keyword=OPC-31260 kn-keyword=OPC-31260 END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=5 article-no= start-page=247 end-page=252 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Diuretic effect of cilazapril and dopamine system in the spontaneously hypertensive rat. en-subtitle= kn-subtitle= en-abstract= kn-abstract=<p>To assess the role of the kidney dopamine system on the diuretic state induced by angiotensin-converting enzyme (ACE) inhibitors, we examined the changes in urinary excretion and plasma level of dopamine, and kidney dopamine receptors in spontaneously hypertensive rats (SHR) treated with cilazapril, an ACE inhibitor. We administered cilazapril 10 mg/kg orally to 13-week-old SHR daily for 21 days (CILAZA group). Systolic blood pressure was significantly decreased in the CILAZA group on Day 6 compared with that in vehicle-treated SHR (control group). The urine volume was three- to fivefold higher in the CILAZA group, and total urinary dopamine secretion was also increased compared with the control group. There was no significant difference in affinity and number of kidney dopamine receptors between the CILAZA and the control groups. In conclusion, the diuretic effect caused by cilazapril is partly mediated by inhibition of the water reabsorption via the increase of dopamine production in the kidney.</p>
en-copyright= kn-copyright= en-aut-name=WatanabeHitoshi en-aut-sei=Watanabe en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HosoyaMasaharu en-aut-sei=Hosoya en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishidaNorikazu en-aut-sei=Nishida en-aut-mei=Norikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=dopamine kn-keyword=dopamine en-keyword=ACE inhibitor kn-keyword=ACE inhibitor en-keyword=cilazapril kn-keyword=cilazapril en-keyword=SHR kn-keyword=SHR en-keyword=kidney kn-keyword=kidney END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=4 article-no= start-page=187 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats. en-subtitle= kn-subtitle= en-abstract= kn-abstract=We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.
en-copyright= kn-copyright= en-aut-name=MimuraYukari en-aut-sei=Mimura en-aut-mei=Yukari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamauchiTakayoshi en-aut-sei=Yamauchi en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OishiTetsuya en-aut-sei=Oishi en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HaradaKazushi en-aut-sei=Harada en-aut-mei=Kazushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HashimotoMasami en-aut-sei=Hashimoto en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University en-keyword=vasopressin kn-keyword=vasopressin en-keyword=DOCA-salt hypertensive rat kn-keyword=DOCA-salt hypertensive rat en-keyword=V1-and V2-receptor antagonist kn-keyword=V1-and V2-receptor antagonist en-keyword= spontaneously hypertesive rat(SHR) kn-keyword= spontaneously hypertesive rat(SHR) en-keyword=OPC-21268 kn-keyword=OPC-21268 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=655 end-page=661 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maintenance therapy with erythropoietin for renal anemia kn-title=腎性貧血に対するエリスロポエチンの維持投与法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The beneficial effect of recombinant human erythropoietin (EPO) for renal anemia in patients with chronic hemodialysis has been esthablishel. EPO is reported to be effective against renal anemia when adeministered at a dose 3,000 units three times a week. However, only a few studies have been made on the therapy to maintain the anemia-improving effect of EPO. In the present study, we performed EPO maintenance therapy on 22 hemodialysis patients with renal anemia. EPO was initialy administered at a dose of 3,000 units three times a week, and maintenance therapy was initiated after 12 weeks of treatment. The patients were divided into two groups, with EPO being administered at a dose of 1,500 units twice a week to one group and three times a week to the other. The duration of maintenance therapy was set at eight weeks. The anemia-improving effect of EPO was found to be satisfactorily maintained in both groups and no significant difference was noted between them. According, it may be better to use the lower dose regimen of 1,500 units twice a week for the maintenance therapy of renal anemia. en-copyright= kn-copyright= en-aut-name=OguraTosio en-aut-sei=Ogura en-aut-mei=Tosio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HiramatsuMakoto en-aut-sei=Hiramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=維持投与法 kn-keyword=維持投与法 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Improvement of anemia by erythropoietin and changes in hemodialysis efficiency kn-title=エリスロポエチン投与による貧血改善と透析効率の変化に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The administration of recombinant human erythropoietin (EPO) has considerably improved renal anemia in benodialysis patients. However, there is a possibility that plasma flow will decrease and cause a reduction of hemodialysis effciency after the improvement of anemia. In the present study, we examined the influence of the improvement of anemia EPO administration on the efficiency of dialysis in 44 hemodialysis patients with renal anemia (21 males and 23 females ; mean age : 59.5±14.6 years). Epo was administered at a dose of 3,000 units three times a week and the duration of treatment was generally 12 weeks. EPO treatment significantly improved anemia. However, the blood urea nitrogen, creatinine, and uric acid levels before and after dialysis as well as the potassium and phosporus levels before dialysis showed no significant changes after the improvement of renal anemia. Accordingly. it is unnecessary to take any specific measures to improve the efficiency of dialysis after treating renal anemia with EPO. en-copyright= kn-copyright= en-aut-name=MakinoHirohumi en-aut-sei=Makino en-aut-mei=Hirohumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HaramatsuMakoto en-aut-sei=Haramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=透析効率 kn-keyword=透析効率 END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=3-8 article-no= start-page=85 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Present status and problems of visiting nurse station kn-title=病院基盤の訪問看護ステーションの問題点 ―患者67名からの検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the curent status of home nursing in our instiution, and visiting nurses' station "chime", to clarify current problems and possible improvements in home care service. A large number of the subjects were aged, and had various diseases usually involving cerebrovascular disorder. Patients requiring medical treatment comprised less than half, and it was considered that support was strong in the current home nursing siuation, particulrly. We examined the age status of persons who looked after the patients, and tce burden on women who provided care. Furthemore, problems with the prenent visit nursing syntem were evaluated by an anonymous questionnaire survey of patients and their attendants. Many of the subjects were worried or troubled about what to do about exacerbation or sudden chages of he patients' condition, the health of the caretakers, and the tight schedule of the caretakers' life. Based on the results of this questionnaire, we would like to improve the cooperation among members the visting nurse staff including doctors, and physiotherapists so that each of them may better play their roles and provide more appropriate nursing based on the wishes and needs of indvidual patients patients and their caretakers rather than those of the uniform service. en-copyright= kn-copyright= en-aut-name=MimuraYukari en-aut-sei=Mimura en-aut-mei=Yukari kn-aut-name=三村由香里 kn-aut-sei=三村 kn-aut-mei=由香里 aut-affil-num=1 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=2 ORCID= en-aut-name=OkaYouko en-aut-sei=Oka en-aut-mei=Youko kn-aut-name=岡庸子 kn-aut-sei=岡 kn-aut-mei=庸子 aut-affil-num=3 ORCID= en-aut-name=WatanabeKimiko en-aut-sei=Watanabe en-aut-mei=Kimiko kn-aut-name=渡辺君子 kn-aut-sei=渡辺 kn-aut-mei=君子 aut-affil-num=4 ORCID= en-aut-name=KanamiHifumi en-aut-sei=Kanami en-aut-mei=Hifumi kn-aut-name=金見一ニ三 kn-aut-sei=金見 kn-aut-mei=一ニ三 aut-affil-num=5 ORCID= en-aut-name=MoriwakiKazuhiko en-aut-sei=Moriwaki en-aut-mei=Kazuhiko kn-aut-name=森脇和彦 kn-aut-sei=森脇 kn-aut-mei=和彦 aut-affil-num=6 ORCID= en-aut-name=KatayamaEriko en-aut-sei=Katayama en-aut-mei=Eriko kn-aut-name=片山江里子 kn-aut-sei=片山 kn-aut-mei=江里子 aut-affil-num=7 ORCID= en-aut-name=FujiwaraHiromichi en-aut-sei=Fujiwara en-aut-mei=Hiromichi kn-aut-name=藤原弘道 kn-aut-sei=藤原 kn-aut-mei=弘道 aut-affil-num=8 ORCID= en-aut-name=SadakaneTakazi en-aut-sei=Sadakane en-aut-mei=Takazi kn-aut-name=定金卓爾 kn-aut-sei=定金 kn-aut-mei=卓爾 aut-affil-num=9 ORCID= en-aut-name=SatouYoshiyuki en-aut-sei=Satou en-aut-mei=Yoshiyuki kn-aut-name=佐藤能之 kn-aut-sei=佐藤 kn-aut-mei=能之 aut-affil-num=10 ORCID= en-aut-name=HayashiIppei en-aut-sei=Hayashi en-aut-mei=Ippei kn-aut-name=林逸平 kn-aut-sei=林 kn-aut-mei=逸平 aut-affil-num=11 ORCID= en-aut-name=SatouKamehiro en-aut-sei=Satou en-aut-mei=Kamehiro kn-aut-name=佐藤亀弘 kn-aut-sei=佐藤 kn-aut-mei=亀弘 aut-affil-num=12 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学内科学第三講座 affil-num=2 en-affil= kn-affil=岡山大学内科学第三講座 affil-num=3 en-affil= kn-affil=明芳会訪問介護ステーション affil-num=4 en-affil= kn-affil=明芳会訪問介護ステーション affil-num=5 en-affil= kn-affil=明芳会佐藤病院 affil-num=6 en-affil= kn-affil=明芳会佐藤病院 affil-num=7 en-affil= kn-affil=明芳会佐藤病院 affil-num=8 en-affil= kn-affil=明芳会佐藤病院 affil-num=9 en-affil= kn-affil=明芳会佐藤病院 affil-num=10 en-affil= kn-affil=明芳会佐藤病院 affil-num=11 en-affil= kn-affil=明芳会佐藤病院 affil-num=12 en-affil= kn-affil=明芳会佐藤病院 affil-num=13 en-affil= kn-affil=岡山大学保健管理センター en-keyword=在宅医療 kn-keyword=在宅医療 en-keyword=訪問看護 kn-keyword=訪問看護 en-keyword=脳血管障害 kn-keyword=脳血管障害 en-keyword=痴呆 kn-keyword=痴呆 en-keyword=ADL (activing of daily living) kn-keyword=ADL (activing of daily living) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19890630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高血圧自然発症ラット腎における心房性ナトリウム利尿ペプチド受容体の週齢による変化 kn-title=Developmental Change of Kidney Receptor for Atrial Natriuretic Factor in Spontaneously Hypertensive Rat en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END