start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=3
article-no=
start-page=285
end-page=289
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol
than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive
effects. Further investigation of the antinociceptive mechanism of landiolol is required.
en-copyright=
kn-copyright=

en-aut-name=MizobuchiSatoshi
en-aut-sei=Mizobuchi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuokaYoshikazu
en-aut-sei=Matsuoka
en-aut-mei=Yoshikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ObataNorihiko
en-aut-sei=Obata
en-aut-mei=Norihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KakuRyuji
en-aut-sei=Kaku
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ItanoYoshitaro
en-aut-sei=Itano
en-aut-mei=Yoshitaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TomotsukaNaoto
en-aut-sei=Tomotsuka
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TaniguchiArata
en-aut-sei=Taniguchi
en-aut-mei=Arata
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NishieHiroyuki
en-aut-sei=Nishie
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KanzakiHirotaka
en-aut-sei=Kanzaki
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MoritaKiyoshi
en-aut-sei=Morita
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=2
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=3
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=4
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=5
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=6
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=7
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=8
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine

affil-num=9
en-affil=
kn-affil=Department of Biomedical Sciences, Cedars-sinai Medical Center

affil-num=10
en-affil=
kn-affil=Departments of Molecular Genetics, Okayama University Graduate School of Medicine

affil-num=11
en-affil=
kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
en-keyword=beta-blocker
kn-keyword=beta-blocker
en-keyword=landiolol
kn-keyword=landiolol
en-keyword=formalin
kn-keyword=formalin
en-keyword=pain behavior
kn-keyword=pain behavior
en-keyword=c-fos
kn-keyword=c-fos
END