| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Misawa, Haruo| Takigawa, Tomoyuki| Yamane, Kentaro| Tsuji, Hironori| Takei, Yoshitaka| Ozaki, Toshifumi| |
| キーワード | Peripheral neuropathic pain Mirogabalin Pregabalin Adverse event |
| 発行日 | 2020-05-26 |
| 出版物タイトル | Journal of Orthopaedic Surgery and Research |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | Springer |
| 開始ページ | 191 |
| ISSN | 1749-799X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 32456647 |
| DOI | 10.1186/s13018-020-01709-3 |
| Web of Science KeyUT | 000538017400002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s13018-020-01709-3 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ohtsuki, Takashi| Hatipoglu, Omer F.| Asano, Keiichi| Inagaki, Junko| Nishida, Keiichiro| Hirohata, Satoshi| |
| キーワード | cell migration-inducing hyaluronidase 1 (CEMIP) chondrocyte hyaluronan mechanical strain nuclear factor kappa B (NF-kappa B) osteoarthritis |
| 発行日 | 2020-04-29 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 21巻 |
| 号 | 9号 |
| 出版者 | MDPI |
| 開始ページ | 3140 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32365591 |
| DOI | 10.3390/ijms21093140 |
| Web of Science KeyUT | 000535581700111 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms21093140 |
| フルテキストURL | JOS_015_Fulltext.pdf JOS_015_Figures.pptx |
|---|---|
| 著者 | Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Saito, Taichi| Ozaki, Toshifumi| |
| 発行日 | 2020-03-26 |
| 出版物タイトル | Journal of Orthopaedic Science |
| 巻 | 26巻 |
| 号 | 2号 |
| 出版者 | Elsevier |
| 開始ページ | 230 |
| 終了ページ | 236 |
| ISSN | 09492658 |
| NCID | AA11052566 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 The Japanese Orthopaedic Association. |
| 論文のバージョン | author |
| PubMed ID | 32223991 |
| DOI | 10.1016/j.jos.2020.02.015 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jos.2020.02.015 |
| JaLCDOI | 10.18926/AMO/57957 |
|---|---|
| フルテキストURL | 74_1_77.pdf |
| 著者 | Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi| |
| 抄録 | Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. |
| キーワード | idiopathic chondrolysis hip joint medication bump arthroscopy |
| Amo Type | Case Report |
| 発行日 | 2020-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 77 |
| 終了ページ | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099253 |
| Web of Science KeyUT | 000516606200012 |
| NAID | 120006795624 |
| JaLCDOI | 10.18926/AMO/57720 |
|---|---|
| フルテキストURL | 73_6_537.pdf |
| 著者 | Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka| |
| 抄録 | High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty. |
| キーワード | high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery |
| Amo Type | Case Report |
| 発行日 | 2019-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 537 |
| 終了ページ | 542 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871338 |
| Web of Science KeyUT | 000503431400011 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi| |
| 発行日 | 2019-10-15 |
| 出版物タイトル | Experimental Cell Research |
| 巻 | 383巻 |
| 号 | 2号 |
| 出版者 | Elsevier |
| 開始ページ | 111556 |
| ISSN | 00144827 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 The Authors. Published by Elsevier Inc. |
| 論文のバージョン | publisher |
| PubMed ID | 31415758 |
| DOI | 10.1016/j.yexcr.2019.111556 |
| Web of Science KeyUT | 000488145400017 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556 |
| 著者 | Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2017-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 71巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/54824 |
| JaLCDOI | 10.18926/AMO/54811 |
|---|---|
| フルテキストURL | 70_6_477.pdf |
| 著者 | Nishida, Keiichiro| Machida, Takahiro| Horita, Masahiro| Hashizume, Kenzo| Nakahara, Ryuichi| Nasu, Yoshihisa| Ohashi, Hideki| Saiga, Kenta| Ozaki, Toshifumi| |
| 抄録 | The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p＜0.001). Twenty-four feet (89 ) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot. |
| キーワード | shortening oblique osteotomy rheumatoid arthritis forefoot screw fixation |
| Amo Type | Original Article |
| 発行日 | 2016-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 477 |
| 終了ページ | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003673 |
| JaLCDOI | 10.18926/AMO/53119 |
|---|---|
| フルテキストURL | 69_1_29.pdf |
| 著者 | Nakahara, Ryuichi| Nishida, Keiichiro| Hashizume, Kenzo| Harada, Ryouzou| Machida, Takahiro| Horita, Masahiro| Ohtsuka, Aiji| Ozaki, Toshifumi| |
| 抄録 | The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r＝0.27), OMERACT total score (r＝0.43) and synovial volume (r＝0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well. |
| キーワード | magnetic resonance imaging rheumatoid arthritis outcome measures in rheumatology clinical trials scoring system direct volume measuring medical work station |
| Amo Type | Original Article |
| 発行日 | 2015-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703168 |
| Web of Science KeyUT | 000349740300003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53113 |
| タイトル（別表記） | Hospital and clinic cooperation for the treatment of rheumatoid arthritis in Okayama Prefecture, Japan |
|---|---|
| フルテキストURL | 126_209.pdf |
| 著者 | 佐田 憲映| 西田 圭一郎| 山中 隆夫| 三崎 健太| 若林 宏| 篠田 潤子| 髙木 徹| 矢野 隆介| 中村 明彦| 難波 良文| 守田 吉孝| 小山 芳伸| 山本 惠嗣| 江澤 和彦| 太田 裕介| 吉原 由樹| 三好 信也| 棗田 将光| 臼井 正明| 吉永 泰彦| 林 充| 山村 昌弘| 橋詰 博行| |
| 抄録 | Objective: To survey the current status and problems of cooperation between clinics and hospitals in Okayama Prefecture, Japan for the treatment of rheumatoid arthritis (RA). Methods: We distributed a questionnaire to 300 of the 983 Okayama Prefecture clinics that had either an internal medicine or orthopedic surgery department, from December 2013 to February 2014. The questionnaire covered practice pattern for RA treatment in clinics, current status of the hospital and clinic cooperation, and acceptance of the biologic therapy. Results: One hundred clinics responded to the questionnaire. Seventy percent of the clinics reported making referrals to rheumatologists before the initiation of RA treatment, and half of the other 30% of the clinics administered methotrexate as the first-line treatment for RA by their own decision. Sixty-six clinics cooperated with flagship hospitals, conducting medical and laboratory examinations, providing prescriptions, and treating common diseases of patients. These clinics expected the cooperating rheumatologists to follow-up patients every 3 to 6 months and to make the diagnosis, make decisions regarding RA treatment changes, and perform surgery. Seventy-one percent of the clinics responded that cooperation with a hospital is possible even for patients who are administered biologics. As reasons for no cooperation with the flagship hospitals, clinics noted the lack of information about rheumatologists in the area and recent trends in the management of RA. Conclusion: The current study reported, for the first time, the actual conditions of management of RA in clinics, as well as future problems of hospital and clinic cooperation in Okayama Prefecture. |
| キーワード | 病診連携（hospital and clinic cooperation） 関節リウマチ（rheumatoid arthritis） 生物学的製剤（biologics） メトトレキサート（methotrexate） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2014-12-01 |
| 巻 | 126巻 |
| 号 | 3号 |
| 開始ページ | 209 |
| 終了ページ | 215 |
| ISSN | 0030-1558 |
| 言語 | Japanese |
| 著作権者 | Copyright (c) 2014 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.126.209 |
| NAID | 130004903246 |
| JaLCDOI | 10.18926/AMO/51867 |
|---|---|
| フルテキストURL | 67_5_311.pdf |
| 著者 | Nishida, Keiichiro| Hashizume, Hiroyuki| Matsukawa, Akihiro| Hashizume, Kenzo| Shimamura, Yasunori| Torigoe, Yasuyuki| Ozaki, Toshifumi| |
| 抄録 | We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up. |
| キーワード | occult compression fracture metacarpal head avascular necrosis osteochondral autograft |
| Amo Type | Case Report |
| 発行日 | 2013-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 317 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24145731 |
| Web of Science KeyUT | 000325836100005 |
| JaLCDOI | 10.18926/AMO/49255 |
|---|---|
| フルテキストURL | 67_1_35.pdf |
| 著者 | Watanabe, Masutaka| Arita, Seizaburo| Hashizume, Hiroyuki| Honda, Mitsugi| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from 1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage was investigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R＝0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification. |
| キーワード | cubital tunnel syndrome ulnar nerve Akahoriʼs classification multiple regression analysis |
| Amo Type | Original Article |
| 発行日 | 2013-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439507 |
| Web of Science KeyUT | 000316829900005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50647 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 発行日 | 2011-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| 著者 | 島村 安則| 井上 円加| 小澤 正嗣| 金澤 智子| 斎藤 太一| 中原 龍一| 野田 知之| 西田 圭一郎| 尾﨑 敏文| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40012 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Sasaki, Kentaro| Senda, Masuo| Nishida, Keiichiro| Ota, Haruyuki| |
| 抄録 | We examined whether the preoperative time required for the Timed "Up and Go" (TUG) test could predict the risk for deep venous thrombosis (DVT) in patients with hip osteoarthritis after total hip arthroplasty (THA). Eighteen patients with DVT diagnosed by venography were selected, and 18 without DVT of the same age and sex and with the same operated side as the DVT group were selected as a control group. We evaluated the 5 preoperative factors that might affect the occurrence of DVT complications, as follows:disease duration, body mass index, serum total cholesterol, subjective pain evaluated by the visual analog scale, and TUG. The JOA hip score (pain, range of motion, walking ability, and daily life) was also evaluated before surgery. As a postoperative factor, we checked the postoperative day when weight-bearing was initiated. As a result, TUG (DVT, 18.4+/-4.0 sec vs. control, 15.0+/-3.2 sec;p0.01) was only significantly different between the 2 groups. The ROC curve revealed that the cut-off point of 15.3 sec in preoperative time for TUG was sensitive (83.3%) and specific (61.1%) for DVT after THA (odds ratio7.0;95% confidence interval, 1.6-30.8). These results suggested that low preoperative ambulatory ability in patients with hip osteoarthritis might be associated with DVT after THA. An improvement in TUG before surgery might contribute to a decrease in the occurrence of DVT after THA. |
| キーワード | preoperative Timed “Up and Go” test deep venous thrombosis total hip arthroplasty hip osteoarthritis |
| Amo Type | Original Article |
| 発行日 | 2010-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 197 |
| 終了ページ | 201 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596131 |
| Web of Science KeyUT | 000279094300006 |
| JaLCDOI | 10.18926/AMO/32855 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Shimamura, Yasunori| Nishida, Keiichiro| Imatani, Junya| Noda, Tomoyuki| Hashizume, Hiroyuki| Ohtsuka, Aiji| Ozaki, Toshifumi| |
| 抄録 | <p>We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods:an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were:Group I, 98.9+/-32.6;Group II, 108.5+/-27.2;Group III, 50.0+/-7.5;and Group IV, 34.5+/-12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p0.05). In the extension loading test, the mean failure loads were:Group I, 34.0+/-12.4;Group II, 51.0+/-14.8;Group III, 19.3+/-6.0;and Group IV, 14.7+/-3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.</p> |
| キーワード | distal humerus fracture biomechanics internal fixation elderly |
| Amo Type | Original Article |
| 発行日 | 2010-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 120 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20424666 |
| Web of Science KeyUT | 000276996900005 |
| JaLCDOI | 10.18926/AMO/31823 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Misawa, Haruo| Takigawa, Tomoyuki| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.</p> |
| キーワード | Rett syndrome scoliosis computer navigation-assisted surgery segmental pedicle screw fixation |
| Amo Type | Case Report |
| 発行日 | 2009-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20035294 |
| Web of Science KeyUT | 000273145900009 |
| JaLCDOI | 10.18926/AMO/31820 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyake, Kohei| Nishida, Keiichiro| Kadota, Yasutaka| Yamasaki, Hiroko| Nasu, Tatsuyo| Saitou, Daisuke| Tanabe, Katsuyuki| Sonoda, Hikaru| Sato, Yasufumi| Maeshima, Yohei| Makino, Hirofumi| |
| 抄録 | <p>Angiogenesis is an essential event in the development of synovial inflammation in rheumatoid arthritis (RA). The aim of the current study was to investigate the expression of vasohibin-1, a novel endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor, in the RA synovium, and to test the effect of inflammatory cytokines on the expression of vasohibin-1 by RA synovial fibroblasts (RASFs). Synovial tissue samples were obtained at surgery from patients with osteoarthritis (OA) and RA, and subjected to immunohistochemistry to investigate the expression and distribution of vasohibin-1 relevant to the degree of synovial inflammation. In an in vitro analysis, RASFs were used to examine the expression of vasohibin-1 and VEGF mRNA by real-time PCR after stimulation with VEGF or inflammatory cytokines under normoxic or hypoxic conditions. The immunohistochemical results showed that vasohibin-1 was expressed in synovial lining cells, endothelial cells, and synovial fibroblasts. In synovial tissue, there was a significant correlation between the expression of vasohibin-1 and histological inflammation score (p0.002, r0.842). In vitro, stimulation with VEGF induced the expression of vasohibin-1 mRNA in RASFs under normoxic conditions, and stimulation with cytokines induced vasohibin-1 mRNA expression under a hypoxic condition. These results suggest that vasohibin-1 was expressed in RA synovial tissue and might be regulated by inflammatory cytokines.</p> |
| キーワード | angiogenesis vasohibin-1 rheumatoid arthritis synovial membrane VEGF |
| Amo Type | Original Article |
| 発行日 | 2009-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20035291 |
| Web of Science KeyUT | 000273145900006 |
| 著者 | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2009-09-18 |
| 出版物タイトル | Journal of Biomechanics |
| 巻 | 42巻 |
| 号 | 13号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/30974 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ikuma, Hisanori| Abe, Nobuhiro| Uchida, Youichiro| Furumatsu, Takayuki| Fujiwara, Kazuo| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Instability of the knee after the medial collateral ligament (MCL) injury is usually assessed with the manual valgus stress test, even though, in recent years, it has become possible to apply magnetic resonance imaging (MRI) to the assessment of the damage of the ligament. The valgus instability of 24 patients (12 isolated injuries and 12 multiple ligament injuries) who suffered MCL injury between 1993 and 1998 was evaluated with the Hughston and Eilers classification, which involves radiographic assessment under manual valgus stress to the injured knees. We developed a novel system for classifying the degree of injury to the MCL by calculating the percentage of injured area based on MRI and investigated the relationship between this novel MRI classification and the magnitude of valgus instability by the Hughston and Eilers classification. There was a significant correlation between the 2 classifications (p=0.0006). On the other hand, the results using other MRI based classification systems, such as the Mink and Deutsch classificaiton and the Petermann classification, were not correlated with the findings by the Hughston and Eilers classification in these cases (p0.05). Since MRI is capable of assessing the injured ligament in clinical practice, this novel classification system would be useful for evaluating the stability of the knee and choosing an appropriate treatment following MCL injury.</p> |
| キーワード | medial collateral ligament magnetic resonance imaging knee instability novel method |
| Amo Type | Original Article |
| 発行日 | 2008-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 62巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18596835 |
| Web of Science KeyUT | 000257130300006 |