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ID 58207
フルテキストURL
著者
Kobayashi, Terumasa Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maruyama, Takayuki Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID researchmap
Yoneda, Toshiki Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID
Miyai, Hisataka Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Azuma, Tetsuji Department of Community Oral Health, Asahi University School of Dentistry
Tomofuji, Takaaki Department of Community Oral Health, Asahi University School of Dentistry
Ekuni, Daisuke Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Morita, Manabu Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
抄録
Background/aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss.
Materials and methods: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks.
Results: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group.
Conclusion: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.
キーワード
Aging
antioxidant
coffee
oxidative stress
periodontal tissue
発行日
2020-03
出版物タイトル
In Vivo
34巻
2号
出版者
International Institute of Anticancer Research
開始ページ
615
終了ページ
622
ISSN
0258-851X
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios)
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.21873/invivo.11815
Citation
Terumasa Kobayashi, Takayuki Maruyama, Toshiki Yoneda, Hisataka Miyai, Tetsuji Azuma, Takaaki Tomofuji, Daisuke Ekuni, Manabu MoritaIn Vivo 34(2): 615-622, 2020. PMID: 32111761. DOI: 10.21873/invivo.11815