ID | 59927 |
フルテキストURL | |
著者 |
Nomura, Hayato
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Suganuma, Mutsumi
Department of Dermatology, Nagoya University Graduate School of Medicine
Takeichi, Takuya
Department of Dermatology, Nagoya University Graduate School of Medicine
Kono, Michihiro
Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine
Isokane, Yuki
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Sunagawa, Ko
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Kobashi, Mina
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Sugihara, Satoru
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Kajita, Ai
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Miyake, Tomoko
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
ORCID
Kaken ID
Hirai, Yoji
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Yamasaki, Osamu
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Kaken ID
publons
researchmap
Akiyama, Masashi
Department of Dermatology, Nagoya University Graduate School of Medicine
Morizane, Shin
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
ORCID
Kaken ID
publons
researchmap
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抄録 | The serine proteases kallikrein-related peptidase (KLK) 5 and KLK7 cleave cell adhesion molecules in the epidermis. Aberrant epidermal serine protease activity is thought to play an important role in the pathogenesis of atopic dermatitis (AD). We collected the stratum corneum (SC) from healthy individuals (n = 46) and AD patients (n = 63) by tape stripping and then measuring the trypsin- and chymotrypsin-like serine protease activity. We also analyzed the p.D386N and p.E420K of SPINK5 variants and loss-of-function mutations of FLG in the AD patients. The serine protease activity in the SC was increased not only in AD lesions but also in non-lesions of AD patients. We found, generally, that there was a positive correlation between the serine protease activity in the SC and the total serum immunoglobulin E (IgE) levels, serum thymus and activation-regulated chemokine (TARC) levels, and peripheral blood eosinophil counts. Moreover, the p.D386N or p.E420K in SPINK5 and FLG mutations were not significantly associated with the SC's serine protease activity. Epidermal serine protease activity was increased even in non-lesions of AD patients. Such activity was found to correlate with a number of biomarkers of AD. Further investigations of serine proteases might provide new treatments and prophylaxis for AD.
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キーワード | atopic dermatitis
serine proteases
kallikrein-related peptidases
epidermal barrier dysfunction
lympho-epithelial Kazal-type-related inhibitor (LEKTI)
SPINK5
filaggrin
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発行日 | 2020-01-30
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出版物タイトル |
International Journal of Molecular Sciences
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巻 | 21巻
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号 | 3号
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出版者 | MDPI
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開始ページ | 913
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ISSN | 1422-0067
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/ijms21030913
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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