このエントリーをはてなブックマークに追加
ID 57469
Elsevier API for ScienceDirect subscriber
フルテキストURL
著者
Ohmori, Iori Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 科研費研究者番号
Hayashi, Keiichiro Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Wang, Haijiao Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Ouchida, Mamoru Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 科研費研究者番号
Fujita, Naohiro Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Inoue, Takushi Department of Child Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Michiue, Hiroyuki Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 科研費研究者番号
Nishiki, Teiichi Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 科研費研究者番号
Matsui, Hideki Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 科研費研究者番号
抄録
The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined the efficacy of inhalation of 5% or 10% CO2 to treat HISs. HISs were evoked in Scn1a mutant and wild-type (WT) rats by hot water baths. To determine the anticonvulsant effect of CO2 inhalation, rats were placed in a chamber filled with air or mixed gas containing 5% CO2 or 10% CO2 for 3 min, immediately after the induction of HISs. We also analyzed the blood gas levels at the end of inhalation of CO2. Hot water bathing induced a significant reduction in the partial pressure of CO2 (pCO2) and respiratory alkalosis in the WT and Scn1a mutant rats. HISs were evoked in 100% of the Scn1a mutant rats within 5 min, but in none of the WT rats. The Scn1a mutant rats demonstrated a higher HISs susceptibility associated with respiratory alkalosis than the WT rats. Inhalation of 10% CO2 shortened the seizure duration from 62.6±12.1 s to 15.5±1.0 s. Blood gas analysis after the inhalation of 10% CO2 demonstrated an elevated pCO2 level and respiratory acidosis. Inhalation of 10% CO2 demonstrated a potent and fast-acting anticonvulsant effect against HISs.
発行日
2013-07
出版物タイトル
Epilepsy Research
105巻
1-2号
出版者
Elsevier Science
開始ページ
220
終了ページ
224
ISSN
09201211
NCID
AA10726642
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.eplepsyres.2013.01.003
Citation
Iori Ohmori, Keiichiro Hayashi, Haijiao Wang, Mamoru Ouchida, Naohiro Fujita, Takushi Inoue, Hiroyuki Michiue, Teiichi Nishiki, Hideki Matsui, Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures, Epilepsy Research, Volume 105, Issues 1–2, 2013, Pages 220-224, ISSN 0920-1211, https://doi.org/10.1016/j.eplepsyres.2013.01.003.
助成機関名
文部科学省
助成番号
21390312
23659522
22591130