ID | 51468 |
フルテキストURL | |
著者 |
Kurose, Yuko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Wada, Jun
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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Kaken ID
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Kanzaki, Motoko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Teshigawara, Sanae
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Kaken ID
Nakatsuka, Atsuko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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Murakami, Kazutoshi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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Inoue, Kentaro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Terami, Takahiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Katayama, Akihiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Watanabe, Mayu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Higuchi, Chigusa
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Eguchi, Jun
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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Miyatake, Nobuyuki
Kagawa Univ, Fac Med, Dept Hyg
Makino, Hirofumi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
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抄録 | Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T(H)1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such as p27(Kip1) and p21(Cip1).
Methods: We investigated the serum levels of Gal-9 in the patients with type 2 diabetes and various stages of chronic kidney disease (CKD) (n = 182).
Results: Serum Gal-9 levels in the patients with type 2 diabetes were 131.9 +/- 105.4 pg/ml and Log(10)Gal-9 levels significantly and positively correlated with age (r = 0.227, p = 0.002), creatinine (r = 0.175, p = 0.018), urea nitrogen (r = 0.162, p = 0.028) and osmotic pressure (r = 0.187, p = 0.014) and negatively correlated with estimated glomerular filtration rate (eGFR) (r = -0.188, p = 0.011). Log(10)Gal-9 levels increased along with the progression of GFR categories of G1 to G4, and they were statistically significant by Jonckheere-Terpstra test (p = 0.012). Log(10)Gal-9 levels remained similar levels in albuminuria stages of A1 to A3.
Conclusion: The elevation of serum Gal-9 in the patients with type 2 diabetes is closely linked to GFR and they may be related to the alteration of the immune response and inflammation of the patients with type 2 diabetes and CKD.
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キーワード | Type 2 diabetes
Glomerular filtration
Inflammation
Kidney disease
Nephropathy
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発行日 | 2013-01-22
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出版物タイトル |
BMC Nephrology
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巻 | 14巻
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出版者 | Biomed Central Ltd
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ISSN | 1471-2369
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.1186/1471-2369-14-23
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/51451
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |