桑木健志

Local Recurrence and Complications after Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma : A Retrospective Cohort Study Focused on Tumor Location

JaLCDOI	10.18926/AMO/53558
フルテキストURL	69_4_219.pdf
著者	Toshimori, Junichi\| Nouso, Kazuhiro\| Nakamura, Shinichiro\| Wada, Nozomu\| Morimoto, Yuki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Ohnishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
抄録	We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n＝397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2ｵ, 7.4ｵ and 9.5ｵ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (＞2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (＜3mm) were independent predisposing factors for local recurrence after RFA (HR＝1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site.
キーワード	hepatocellular carcinoma radiofrequency ablation ablated margin tumor location
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-08
巻	69巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	226
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26289913
Web of Science KeyUT	000365519100005

著者	Nakanishi, Yutaka\| Shiraha, Hidenori\| Nishina, Shin-ichi\| Tanaka, Shigetomi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Iwamuro, Masaya\| Takaoka, Nobuyuki\| Uemura, Masayuki\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Kobayashi, Yoshiyuki\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2011-01-04
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

著者	Tanaka, Shigetomi\| Shiraha, Hidenori\| Nakanishi, Yutaka\| Nishina, Shin-Ichi\| Matsubara, Minoru\| Horiguchi, Shigeru\| Takaoka, Nobuyuki\| Iwamuro, Masaya\| Kataoka, Junro\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Toshimori, Junichi\| Ohnishi, Hideki\| Takaki, Akinobu\| Nakamura, Shinichiro\| Nouso, Kazuhiro\| Yagi, Takahito\| Yamamoto, Kazuhide\|
発行日	2012-12-01
出版物タイトル	International Journal of Cancer
巻	131巻
号	11号
資料タイプ	学術雑誌論文

Monitoring of CA19-9 and SPan-1 can facilitate the earlier confirmation of progressing pancreatic cancer during chemotherapy

著者	Tsutsumi, Koichiro\| Kawamoto, Hirofumi\| Hirao, Ken\| Sakakihara, Ichiro\| Yamamoto, Naoki\| Noma, Yasuhiro\| Fujii, Masakuni\| Kato, Hironari\| Ogawa, Tsuneyoshi\| Ishida, Etsuji\| Kuwaki, Kenji\| Nouso, Kazuhiro\| Okada, Hiroyuki\| Yamamoto, Kazuhide\|
発行日	2012-09
出版物タイトル	Pancreatology
巻	12巻
号	5号
資料タイプ	学術雑誌論文

Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma

著者	Nishimura, Mamoru\| Takaki, Akinobu\| Tamaki, Naofumi\| Maruyama, Takayuki\| Onishi, Hideki\| Kobayashi, Sayo\| Nouso, Kazuhiro\| Yasunaka, Tetsuya\| Koike, Kazuko\| Hagihara, Hiroaki\| Kuwaki, Kenji\| Nakamura, Shinichiro\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Tomofuji, Takaaki\| Morita, Manabu\| Yamamoto, Kazuhide\|
発行日	2013-01-30
出版物タイトル	Hepatology Research
巻	43巻
号	10号
資料タイプ	学術雑誌論文

Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma

著者	Kinugasa, Hideaki\| Nouso, Kazuhiro\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Nakamura, Shin-ichiro\| Shiraha, Hidenori\| Kuwaki, Kenji\| Hagihara, Hiroaki\| Ikeda, Fusao\| Miyake, Yasuhiro\| Takaki, Akinobu\| Yamamoto, Kazuhide\|
発行日	2012-04
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	4号
資料タイプ	学術雑誌論文

Diagnostic accuracy of narrow-band imaging and pit pattern analysis significantly improved for less-experienced endoscopists after an expanded training program

著者	Higashi, Reiji\| Uraoka, Toshio\| Kato, Jun\| Kuwaki, Kenji\| Ishikawa, Shin\| Saito, Yutaka\| Matsuda, Takahisa\| Ikematsu, Hiroaki\| Sano, Yasushi\| Suzuki, Seiyuu\| Murakami, Yoshitaka\| Yamamoto, Kazuhide\|
発行日	2010-07
出版物タイトル	Gastrointestinal Endoscopy
巻	72巻
号	1号
資料タイプ	学術雑誌論文

The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

著者	Takeuchi, Yasuto\| Ikeda, Fusao\| Moritou, Yuki\| Hagihara, Hiroaki\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Miyake, Yasuhiro\| Ohnishi, Hideki\| Nakamura, Shinichiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2013-03
出版物タイトル	Journal of Gastroenterology
巻	48巻
号	3号
資料タイプ	学術雑誌論文

桑木 健志