タイトル(別表記) Development of head and neck reconstruction and procedures learned from patients
著者 木股 敬裕|
キーワード 頭頸部 再建 合併症 分類
出版物タイトル 岡山医学会雑誌
発行日 2023-12-01
135巻
3号
開始ページ 129
終了ページ 135
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.135.129
言語 日本語
著作権者 Copyright (c) 2023 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.135.129
タイトル(別表記) A 4th step of visual art instruction in medical education
著者 木股 敬裕| 小比賀 美香子| 久保 卓也| 大塚 益美| 岡本 裕子| 福冨 幸| 松本 洋|
出版物タイトル 岡山医学会雑誌
発行日 2023-12-01
135巻
3号
開始ページ 152
終了ページ 157
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.135.152
言語 日本語
著作権者 Copyright (c) 2023 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.135.152
タイトル(別表記) A third step of visual art instruction in medical education : Introduction of visual thinking strategies supported by Okayama Prefectural Museum of Art
著者 木股 敬裕| 小比賀 美香子| 久保 卓也| 大塚 益美| 岡本 裕子| 福冨 幸| 松本 洋|
出版物タイトル 岡山医学会雑誌
発行日 2023-08-01
135巻
2号
開始ページ 85
終了ページ 88
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.135.85
言語 日本語
著作権者 Copyright (c) 2023 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.135.85
JaLCDOI 10.18926/AMO/64356
フルテキストURL 77_1_11.pdf
著者 Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro|
抄録 The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
キーワード breast reconstruction mastectomy brassiere professional bra fitter
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-02
77巻
1号
出版者 Okayama University Medical School
開始ページ 11
終了ページ 19
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36849141
Web of Science KeyUT 000953663800002
フルテキストURL fulltext.pdf
著者 Shinaoka, Akira| Kamiyama, Kazuyo| Yamada, Kiyoshi| Kimata, Yoshihiro|
発行日 2022-01-10
出版物タイトル Scientific Reports
12巻
1号
出版者 Nature Portfolio
開始ページ 309
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022
論文のバージョン publisher
PubMed ID 35013357
DOI 10.1038/s41598-021-03637-6
Web of Science KeyUT 000741645800052
関連URL isVersionOf https://doi.org/10.1038/s41598-021-03637-6
JaLCDOI 10.18926/AMO/61908
フルテキストURL 75_2_243.pdf
著者 Tomita, Yusuke| Shimazu, Yosuke| Kawakami, Masato| Matsumoto, Hiroshi| Fujii, Kentaro| Kameda, Masahiro| Yasuhara, Takao| Suruga, Yasuki| Ota, Tomoyuki| Kimata, Yoshihiro| Kurozumi, Kazuhiko| Date, Isao|
抄録 Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection cavity were reconstructed using a vascularized anterolateral thigh adipofascial flap. His symptoms disappeared, indicating that endoscopic irrigation and reconstruction can effectively address ventriculitis even in patients in critical clinical condition.
キーワード ventriculitis surgical site infection intraventricular antimicrobial therapy anterior skull base surgery
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-04
75巻
2号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 248
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33953433
NAID 120007029879
フルテキストURL fulltext.pdf
著者 Saiga, Miho| Hosoya, Yuko| Utsunomiya, Hiroki| Kuramoto, Yukiko| Watanabe, Satoko| Tomita, Koichi| Aihara, Yukiko| Muto, Mayu| Hikosaka, Makoto| Kawaguchi, Takashi| Miyaji, Tempei| Yamaguchi, Takuhiro| Zenda, Sadamoto| Goto, Aya| Sakuraba, Minoru| Kusano, Taro| Miyabe, Kenta| Kuroki, Tomoaki| Yano, Tomoyuki| Taminato, Mifue| Sekido, Mitsuru| Tsunoda, Yui| Satake, Toshihiko| Doihara, Hiroyoshi| Kimata, Yoshihiro|
キーワード plastic & reconstructive surgery breast surgery breast tumours
発行日 2021
出版物タイトル BMJ Open
11巻
2号
出版者 BMJ Publishing Group
開始ページ e042099
ISSN 2044-6055
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or their employer(s)) 2021.
論文のバージョン publisher
PubMed ID 33589456
DOI 10.1136/bmjopen-2020-042099
Web of Science KeyUT 000620632000002
関連URL isVersionOf https://doi.org/10.1136/bmjopen-2020-042099
フルテキストURL fulltext.pdf
著者 Nakagiri, Ryoko| Watanabe, Satoko| Takabatake, Kiyofumi| Tsujigiwa, Hidetsugu| Watanabe, Toshiyuki| Matsumoto, Hiroshi| Kimata, Yoshihiro|
キーワード bioceramic bone tissue regeneration honeycomb beta-TCP bone remodeling reproduction of morphology
発行日 2020-11-26
出版物タイトル Materials
13巻
23号
出版者 MDPI
開始ページ 5374
ISSN 1996-1944
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 by the authors.
論文のバージョン publisher
PubMed ID 33256248
DOI 10.3390/ma13235374
Web of Science KeyUT 000597482000001
関連URL isVersionOf https://doi.org/10.3390/ma13235374
フルテキストURL fulltext.pdf
著者 Watanabe, Toshiyuki| Takabatake, Kiyofumi| Tsujigiwa, Hidetsugu| Watanabe, Satoko| Nakagiri, Ryoko| Nakano, Keisuke| Nagatsuka, Hitoshi| Kimata, Yoshihiro|
キーワード honeycomb β-TCP bone tissue regeneration bone microenvironment Vertical and Horizontal holes geometrical structure
発行日 2020-10-25
出版物タイトル Materials
13巻
21号
出版者 MDPI
開始ページ 4761
ISSN 1996-1944
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 by the authors.
論文のバージョン publisher
PubMed ID 33113818
DOI 10.3390/ma13214761
Web of Science KeyUT 000589377800001
関連URL isVersionOf https://doi.org/10.3390/ma13214761
フルテキストURL fulltext.pdf
著者 Akita, Shinsuke| Unno, Naoki| Maegawa, Jiro| Kimata, Yoshihiro| Fukamizu, Hidekazu| Yabuki, Yuichiro| Shinaoka, Akira| Sano, Masaki| Kawasaki, Yohei| Fujiwara, Tadami| Hanaoka, Hideki| Mitsukawa, Nobuyuki|
キーワード Indocyanine green fluorescent lymphography Secondary lymphoedema Lymphaticovenular anastomosis
発行日 2020-09
出版物タイトル Contemporary Clinical Trials Communications
19巻
出版者 Elsevier
開始ページ 100595
ISSN 2451-8654
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 32617434
DOI 10.1016/j.conctc.2020.100595
Web of Science KeyUT 000594379900031
関連URL isVersionOf https://doi.org/10.1016/j.conctc.2020.100595
タイトル(別表記) A second step of visual art instruction in medical education : Development of observational and communication skills
フルテキストURL 132_98.pdf
著者 松本 洋| 北口 陽平| 木股 敬裕| 大塚 益美|
出版物タイトル 岡山医学会雑誌
発行日 2020-08-03
132巻
2号
開始ページ 98
終了ページ 101
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.132.98
言語 日本語
著作権者 Copyright (c) 2020 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.132.98
NAID 130007894967
フルテキストURL fulltext.pdf
著者 Matsui, Chihiro| Tokuyama, Eijiro| Senoo, Takaya| Yamada, Kiyoshi| Kameda, Masahiro| Takeuchi, Tetsuo| Kimata, Yoshihiro|
発行日 2020-04
出版物タイトル Plastic and Reconstructive Surgery Global Open
8巻
4号
出版者 Lippincott, Williams & Wilkins
開始ページ e2797
ISSN 2169-7574
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 32440453
DOI 10.1097/GOX.0000000000002797
Web of Science KeyUT 000533878900070
関連URL isVersionOf https://doi.org/10.1097/GOX.0000000000002797
JaLCDOI 10.18926/AMO/57958
フルテキストURL 74_1_83.pdf
著者 Sakurai, Toru| Watanabe, Toshiyuki| Manako, Kensuke| Komagoe, Syo| Mukai, Yuko| Kimata, Yoshiro| Namba, Yuzaburo|
抄録 Nosaka, NobuyukiMastectomy is usually the first and most important surgical procedure in female-to-male (FTM) individuals with gender identity disorder. Nipple reduction is also important in the process of reconstructing the chest wall for a more male appearance. If the nipples remain large after a mastectomy, the results may be disappointing to many FTM transsexuals. Nipple reduction enables these individuals to go to the beach or Japanese public baths, where they may go topless in public. We therefore consider that nipple reduction is indicated for all FTM transsexuals who desire it. There are a variety of methods for the reduction of enlarged nipples for women or non-FTM patients, but only a few reports have described the process used to create masculine-appearing nipples for FTM transsexuals. We developed a novel technique called the Eryngii method for creating male-like nipples using a 4-mm diameter dermal punch knife. The name of the method refers to the Eryngii king trumpet mushroom, which the nipple resembles after the surgical process. The main strength of this method is that it permits the creation of ideal nipples without difficulty. Here we introduce the technique and discuss our history of surgical methods for nipple reduction, including improvements and elaborations.
キーワード nipple reconstruction female-to-male transmen mastectomy top surgery
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 83
終了ページ 87
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099254
Web of Science KeyUT 000516606200013
NAID 120006795625
JaLCDOI 10.18926/AMO/57375
フルテキストURL 73_5_441.pdf
著者 Watanabe, Toshiyuki| Sakurai, Toru| Mukai, Yuko| Kimata, Yoshihiro| Namba, Yuzaburo|
抄録 Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematoma, may still occur. Postoperative hematomas were found in 15 (4.18%) of 358 FTMTS patients who underwent chest contouring surgery at our hospital between 2006 and 2018. Postoperative hematoma was examined retrospectively. The median time to the onset of hematoma was 7 (6-12) h after the initial surgery. The main blood vessels causing bleeding were those in the head-side skin flap region where visual confirmation was difficult and the perforator vessels from the pectoralis major muscle. Intraoperative bleeding and the operation time had a significant impact on the onset of postoperative hematoma. This is the first retrospective study that investigated the blood vessels and other factors contributing to postoperative hematoma development after chest wall contouring.
キーワード female-to-male transsexuals chest wall contouring postoperative hematoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 441
終了ページ 447
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649371
Web of Science KeyUT 000491886600010
JaLCDOI 10.18926/AMO/57369
フルテキストURL 73_5_393.pdf
著者 Yi Yi Cho Thein| Win, Myitzu| Thuzara, Moe| Matsumoto, Hiroshi| Yamada, Kiyoshi| Kimata, Yoshihiro| Leung, Michael|
抄録 Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation.
キーワード microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 393
終了ページ 401
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649365
Web of Science KeyUT 000491886600004
フルテキストURL invivo_33_1_183.pdf
著者 MIZUNO, HIROFUMI| MIYAI, HISATAKA| YOKOI, AYA| KOBAYASHI, TERUMASA| INABU, CHIAKI| MARUYAMA, TAKAYUKI| EKUNI, DAISUKE| MIZUKAWA, NOBUYOSHI| KARIYA, SHIN| NISHIZAKI, KAZUNORI| KIMATA, YOSHIHIRO| MORITA, MANABU|
キーワード Head and neck cancer concurrent chemoradiotherapy creatinine clearance oral mucositis renal dysfunction
発行日 2019-01
出版物タイトル In Vivo
33巻
1号
出版者 The International Institute of Anticancer Research
開始ページ 183
終了ページ 189
ISSN 0258-851X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 30587621
DOI 10.21873/invivo.11457
Web of Science KeyUT 000454333900027
関連URL isVersionOf https://doi.org/10.21873/invivo.11457
JaLCDOI 10.18926/AMO/55437
フルテキストURL 71_5_399.pdf
著者 Mukai, Yuko| Watanabe, Toshiyuki| Sugimoto, Morito| Kimata, Yoshihiro| Namba, Yuzaburo|
抄録 Many vaginoplasty techniques have been introduced to improve the outcomes of sex reassignment surgery for male-to-female transsexuals. Some vaginoplasty patients still require additional skin grafts, making dilation mandatory to overcome shrinkage. We developed a new vaginoplasty method (called the “pudendal-groin flap”) that uses pudendal-groin flaps. One of this procedure’s advantages is that skin grafts are unnecessary, even for patients with small penises and scrotums. We introduce the procedure here and describe our evaluation of its utility. We retrospectively analyzed the cases of the 15 patients who underwent vaginoplasty using pudendal-groin flaps from May 2010 to January 2016 at our institution. We compared the complications as well as the functional and aesthetic outcomes with those of previous studies. The most common complication was bleeding, which occurred at the corpus spongiosum or while creating a new vaginal cavity. Bleeding can be reduced with more careful hemostasis and dissection. Aside from inadequate vaginal depth in one patient, the incidence of other complications, sexual intercourse, and aesthetic outcomes were acceptable. The pudendal- groin flap is thin and pliable and can create sufficient vaginal depth without skin grafts. The resulting scar is inconspicuous. Our findings suggest that vaginoplasty using the pudendal-groin flap method is feasible.
キーワード vaginoplasty male-to-female transsexuals pudendal-groin flap
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-10
71巻
5号
出版者 Okayama University Medical School
開始ページ 399
終了ページ 405
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29042697
JaLCDOI 10.18926/AMO/55312
フルテキストURL 71_4_345.pdf
著者 Tanaka, Masato| Sugimoto, Yoshihisa| Takigawa, Tomoyuki| Kimata, Yoshihiro| Ozaki, Toshifumi|
抄録 Osteoradionecrosis (ORN), a well-known complication of radiotherapy in the mandibular bone, is very rare in the cervical spine. The authors report the result of a 3-year follow-up of a 63-year-old female patient with ORN of the cervical spine. The patient had a history of laryngeal carcinoma and was treated with chemotherapy and radiation therapy with a total of 120 Gy. Eight years later, she developed acute, severe neck pain due to cervical spine necrosis. The authors performed vascularized fibular bone graft and posterior pedicle screw fixation to reconstruct her cervical spine. The patient was successfully treated with surgery, and cervical alignment was preserved. She had neither neurological deficits nor severe neck pain at her final follow-up 3 years later. Delaying treatment of ORN may be life threatening, so the early diagnosis of this condition is important for patients who receive radiotherapy. Otolaryngologists and spine surgeons should understand this potential complication to speed diagnosis and treatment as early as possible.
キーワード osteoradionecrosis laryngeal carcinoma cervical spine radiotherapy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2017-08
71巻
4号
出版者 Okayama University Medical School
開始ページ 345
終了ページ 349
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28824191
JaLCDOI 10.18926/AMO/54986
フルテキストURL 71_2_171.pdf
著者 Yamada, Kiyoshi| Shinaoka, Akira| Kimata, Yoshihiro|
抄録 As a new trial, we used interstitial computed tomography-lymphography (CT-LG) in 10 patients with lower extremity lymphedema (n=20 limbs) at stage 0, 1, 2, or 3 under the International Society of Lymphology (ISL) classification. In all cases, CT-LG, lymphoscintigraphy, and indocyanine green fluorescence-lymphography (ICG-LG) were performed. In the examination of the ascending level of depicted lymphatic vessels, we measured the diameters of lymphatic vessels detected with CT-LG and conducted an image analysis of dermal backflow of lymph (DB). CT-LG had better resolution than lymphoscintigraphy and enabled the clear visualization of lymphatic vessels with a minimum lumen size of 0.7 mm. CT-LG also showed the three-dimensional architecture of the DB, which originated from deep lymphatic collectors via branched small lymphatic vessels. Our findings are quite valuable not only for detailed examinations of lymphedematous sites and for the lymphedema surgery, but also for investigations of the pathogenesis of lymphedema which has not yet been established. We observed that lymphoscintigraphy could show the lymphatic vessels up to the thigh level in all cases, whereas CT-LG enabled the vessels’ visualization up to the leg level at maximum. In conclusion, CT-LG provided adequate and detailed three-dimensional imaging of the lymphatic system in lymphedema patients.
キーワード interstitial lymphography CT lymphography lymphedema lympatic imaging
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-04
71巻
2号
出版者 Okayama University Medical School
開始ページ 171
終了ページ 177
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28420899
フルテキストURL BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf
著者 Saiga, Miho| Taira, Naruto| Kimata, Yoshihiro| Watanabe, Satoko| Mukai, Yuko| Shimozuma, Kojiro| Mizoo, Taeko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi|
キーワード BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction
発行日 2017-03
出版物タイトル Breast Cancer
24巻
2号
出版者 Japanese Breast Cancer Society
開始ページ 288
終了ページ 298
ISSN 1340-6868
NCID AA1103354X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27179527
DOI 10.1007/s12282-016-0703-6
Web of Science KeyUT 000395524900012
関連URL isVerionOf https://doi.org/10.1007/s12282-016-0703-6