ID | 30729 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ohta, Takeyuki
Okayama University
Sakaguchi, Kohsaku
Okayama University
Fujiwara, Akiko
Okayama University
Fujioka, Shin-ichi
Okayama University
Makino, Yasuhiro
National Hospital Organization Iwakuni Clinical Center
Araki, Yasuyuki
Hiroshima City Hospital
Shiratori, Yasushi
Okayama University
|
抄録 | This study was conducted to develop a simple surrogate index comprised of routinely available laboratory tests to reflect the histological fibrosis stage. Clinical characteristics and laboratory data from 368 and 249 consecutive patients with chronic hepatitis C, a training cohort and a validation cohort, respectively, were retrospectively evaluated. Platelet (Plt) count and albumin (Alb) level contributed to the discrimination of the respective fibrosis stages. We derived the fi brosis index (FI), FI = 8.0-0.01 x Plt (10 multiply 3/microliter) - Alb (g/dl), from a multiple regression model. FI significantly correlated with the histological fibrosis stage in both the initial and validation cohort at p=0.691 and p=0.661, respectively (Spearman's rank correlation coefficient, p<0.0001). The sensitivity and positive predictive value of FI at a cutoff value < 2.10 for predicting fibrosis stage F0-1 were 66.8% and 78.8% in the initial cohort and 68.5% and 63.6% in the validation cohort, respectively. Corresponding values of FI at a cutoff value >- 3.30 for the prediction of F4 were 67.7% and 75.0% in the initial cohort and 70.8% and 81.0% in the validation cohort. The fibrosis index comprised of platelet count and albumin level reflected the histological fibrosis stage in patients with chronic hepatitis C. |
キーワード | albumin level
chronic hepatitis C
fi brosis index
fi brosis stage
platelet count
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2006-04
|
巻 | 60巻
|
号 | 2号
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出版者 | Okayama University Medical School
|
開始ページ | 77
|
終了ページ | 84
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |