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ID 61407
フルテキストURL
著者
Okada, Tomoaki Department of Cardiology, Kagawa Prefectural Central Hospital
Miyoshi, Toru Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons
Doi, Masayuki Department of Cardiology, Kagawa Prefectural Central Hospital
Seiyama, Kosuke Department of Cardiology, Kagawa Prefectural Central Hospital
Takagi, Wataru Department of Cardiology, Kagawa Prefectural Central Hospital
Sogo, Masahiro Department of Cardiology, Kagawa Prefectural Central Hospital
Nosaka, Kazumasa Department of Cardiology, Kagawa Prefectural Central Hospital
Takahashi, Masahiko Department of Cardiology, Kagawa Prefectural Central Hospital
Okawa, Keisuke Department of Cardiology, Kagawa Prefectural Central Hospital
Ito, Hiroshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
抄録
Despite intensive lipid-lowering interventions, patients treated with statins develop atherosclerotic cardiovascular disease (ASCVD), and these patients have an increased risk of developing recurrent cardiovascular events during follow-up. Therefore, there is a need to focus on the residual risks in patients in statin therapy to further reduce ASCVD. The aim of this study was to retrospectively investigate the 10-year trend (2011-2019) regarding changes in polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS) in a single center. We included 686 men and 203 women with ACS admitted to Kagawa Prefectural Central Hospital. Plasma PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA), were measured at admission for suspected ACS. A secular decreasing trend in the levels of EPA and DHA and the EPA/AA ratio, but not of AA and DGLA, was observed. The analyses based on age (>70 or <70 years) and sex showed that the decreasing trend in the levels of EPA and DHA did not depend on age and remained significant only in men. Further studies are needed to obtain robust evidence to justify that the administration of n-3 PUFA contributes to the secondary prevention of ACS.
キーワード
atherosclerotic cardiovascular disease
polyunsaturated fatty acids
eicosapentaenoic acid
docosahexaenoic acid
arachidonic acid
descriptive study
発行日
2021-01-17
出版物タイトル
Nutrients
13巻
1号
出版者
MDPI
開始ページ
253
ISSN
2072-6643
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
© 2021 by the authors.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3390/nu13010253
ライセンス
http://creativecommons.org/licenses/by/4.0/