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ID 52811
フルテキストURL
著者
Dan, Kazuhiro Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Miyoshi, Toru Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Ueeda, Masayuki Mitoyo Gen Hosp, Dept Cardiovasc Med
Ohtsuka, Hiroaki Mitoyo Gen Hosp, Dept Cardiovasc Med
Ugawa, Satoko Mitoyo Gen Hosp, Dept Cardiovasc Med
Ohnishi, Nobuhiko Mitoyo Gen Hosp, Dept Cardiovasc Med
Takaishi, Atsushi Mitoyo Gen Hosp, Dept Cardiovasc Med
Nakamura, Kazufumi Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Kusano, Kengo Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Ito, Hiroshi Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
抄録
Background: Renal insufficiency plays a critical role in the pathogenesis of ischemic heart disease. The aim of the present study was to investigate the prevalence of renal dysfunction and its impact on prognosis in patients with left main coronary artery disease (LMCAD) and stable angina pectoris. Methods and Results: A total of 626 consecutive patients with significant coronary artery stenosis were enrolled. Renal insufficiency was graded using estimated glomerular filtration rate (eGFR) before coronary angiography. Chronic kidney disease (CKD) was defined as eGFR <60 ml.min(-1) 1.73 m(-2) and/or proteinuria. Patients with LMCAD (n=95) had a significantly higher prevalence of CKD than those without LMCAD (P=0.02). Multiple logistic regression analysis showed that CKD was independently associated with LMCAD (adjusted odds ratio, 1.74; 95% confidence interval [CI]: 1.09-2.76, P=0.01). A 1-year follow-up of patients with LMCAD showed that the cumulative incidence of major adverse cardiovascular events among patients with eGFR <30 ml.min(-1).1.73 m(-2) was higher than that among patients with eGFR >= 60 ml.min(-1).1.73 m(-2) (P=0.03). The hazard ratio for a cardiovascular event was 9.54 (95% CI: 3.15-28.89, P<0.01) when comparing patients with LMCAD and eGFR <30 ml.min(-1).1.73 m(-2) vs. patients without LMCAD and eGFR >= 60 ml.min(-1).1.73 m(-2). Conclusions: Renal insufficiency is a risk factor for LMCAD and predicts poor prognosis in Japanese patients.
キーワード
Chronic kidney disease
Coronary artery disease
Left main coronary artery
Risk factor
発行日
2012-09
出版物タイトル
Circulation Journal
76巻
9号
開始ページ
2266
終了ページ
2272
ISSN
1346-9843
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52537
言語
English
著作権者
© 2012 THE JAPANESE CIRCULATION SOCIETY
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT