Acta Medica Okayama60512004Reactivity of TEMPO anion as a nucleophile and its applications for selective transformations of haloalkanes or acyl halides to aldehydes1196911975ENTsutomuInokuchiHiroyukiKawafuchi<p>Sodium 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO−Na+), generated by reduction of TEMPO· with sodium naphthalenide in THF, reacted with alkyl halides or acyl halides to produce O-alkylated or acylated TEMPOs, which were in turn oxidized with mCPBA or reduced with DIBAL-H to afford the corresponding aldehydes, thus accomplishing a new protocol for the halides-carbonyls conversion.</p>
No potential conflict of interest relevant to this article was reported.MDPIActa Medica Okayama1420-304924112019Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative ActivityENNingWangDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityMartaŚwitalskaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesLi WangDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityElkhabiryShabanDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityMd ImranHossainDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityIbrahim El Tantawy El SayedDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityJoannaWietrzykHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesTsutomuInokuchiDivision of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama UniversityCryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. No potential conflict of interest relevant to this article was reported.