start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=51 article-no= start-page=11969 end-page=11975 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reactivity of TEMPO anion as a nucleophile and its applications for selective transformations of haloalkanes or acyl halides to aldehydes en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Sodium 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO−Na+), generated by reduction of TEMPO? with sodium naphthalenide in THF, reacted with alkyl halides or acyl halides to produce O-alkylated or acylated TEMPOs, which were in turn oxidized with mCPBA or reduced with DIBAL-H to afford the corresponding aldehydes, thus accomplishing a new protocol for the halides-carbonyls conversion.

en-copyright= kn-copyright= en-aut-name=InokuchiTsutomu en-aut-sei=Inokuchi en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawafuchiHiroyuki en-aut-sei=Kawafuchi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Toyama National College of Technology en-keyword=TEMPO and compounds kn-keyword=TEMPO and compounds en-keyword=Oxidation kn-keyword=Oxidation en-keyword=Reduction kn-keyword=Reduction en-keyword=mCPBA kn-keyword=mCPBA en-keyword=DIBAL-H kn-keyword=DIBAL-H en-keyword=Aldehyde kn-keyword=Aldehyde END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=11 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. en-copyright= kn-copyright= en-aut-name=WangNing en-aut-sei=Wang en-aut-mei=Ning kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=?witalskaMarta en-aut-sei=?witalska en-aut-mei=Marta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangLi en-aut-sei=Wang en-aut-mei=Li kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShabanElkhabiry en-aut-sei=Shaban en-aut-mei=Elkhabiry kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HossainMd Imran en-aut-sei=Hossain en-aut-mei=Md Imran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=El SayedIbrahim El Tantawy en-aut-sei=El Sayed en-aut-mei=Ibrahim El Tantawy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WietrzykJoanna en-aut-sei=Wietrzyk en-aut-mei=Joanna kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=InokuchiTsutomu en-aut-sei=Inokuchi en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences kn-affil= affil-num=3 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences kn-affil= affil-num=8 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=cryptolepine kn-keyword=cryptolepine en-keyword=neocryptolepine kn-keyword=neocryptolepine en-keyword=isocryptolepine kn-keyword=isocryptolepine en-keyword=antiproliferative activity kn-keyword=antiproliferative activity en-keyword=structure activity relationships kn-keyword=structure activity relationships END