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ID 54912
Sort Key
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タイトル(別表記)
Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone
フルテキストURL
Thumnail 129_23.pdf 17.1 MB
著者
岩野 英二 鴨方クリニック
岩室 雅也 岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 ORCID Kaken ID researchmap
岡田 裕之 岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 Kaken ID researchmap
抄録
Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were < 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n=118) , followed by hyperplastic polyp ( n=52) and inflammatory changes with edema ( n=22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term.
キーワード
アントラセン誘導体(anthracene derivatives)
アントラキノン(anthraquinone)
大腸黒皮症(melanosis coli)
大腸メラノーシス(pseudomelanosis coli)
リンパ濾胞過形成(lymphoid follicle hyperplasia)
備考
原著(Originals)
出版物タイトル
岡山医学会雑誌
発行日
2017-04-03
129巻
1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
23
終了ページ
30
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
OAI-PMH Set
岡山大学
言語
Japanese
著作権者
Copyright (c) 2017 岡山医学会
論文のバージョン
publisher
査読
有り
DOI
NAID
Eprints Journal Name
joma