start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=19 article-no= start-page=5901 end-page=5904 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A en-subtitle= kn-subtitle= en-abstract= kn-abstract=Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. en-copyright= kn-copyright= en-aut-name=IshimotoHidekazu en-aut-sei=Ishimoto en-aut-mei=Hidekazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataMari en-aut-sei=Shibata en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MyojinYuki en-aut-sei=Myojin en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItoHideyuki en-aut-sei=Ito en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaiAkihiro en-aut-sei=Tai en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima affil-num=7 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Ellagitannin kn-keyword=Ellagitannin en-keyword=Urolithin A kn-keyword=Urolithin A en-keyword=Antioxidant activity kn-keyword=Antioxidant activity en-keyword=Anti-inflammatory activity kn-keyword=Anti-inflammatory activity END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=4 article-no= start-page=500 end-page=509 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polyphenol levels in human urine after intake of six different polyphenol-rich beverages en-subtitle= kn-subtitle= en-abstract= kn-abstract=Dietary polyphenols are suggested to participate in the prevention of CVD and cancer. It is essential for epidemiological studies to be able to compare intake of the main dietary polyphenols in populations. The present paper describes a fast method suitable for the analysis of polyphenols in urine, selected as potential biomarkers of intake. This method is applied to the estimation of polyphenol recovery after ingestion of six different polyphenol-rich beverages. Fifteen polyphenols including mammalian lignans (enterodiol and enterolactone), several phenolic acids (chlorogenic, caffeic, m-coumaric, gallic, and 4-Omethylgallic acids), phloretin and various flavonoids (catechin, epicatechin, quercetin, isorhamnetin, kaempferol, hesperetin, and naringenin) were simultaneously quantified in human urine by HPLC coupled with electrospray ionisation mass-MS (HPLC-electrospray-tandem mass spectrometry) with a run time of 6 min per sample. The method has been validated with regard to linearity, precision, and accuracy in intra- and inter-day assays. It was applied to urine samples collected from nine volunteers in the 24 h following consumption of either green tea, a grape-skin extract, cocoa beverage, coffee, grapefruit juice or orange juice. Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively. en-copyright= kn-copyright= en-aut-name=ItoHideyuki en-aut-sei=Ito en-aut-mei=Hideyuki kn-aut-name=伊東秀之 kn-aut-sei=伊東 kn-aut-mei=秀之 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Marie-PauleGonthier kn-aut-sei=Marie-Paule kn-aut-mei=Gonthier aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ClaudineManach kn-aut-sei=Claudine kn-aut-mei=Manach aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChristineMorand kn-aut-sei=Christine kn-aut-mei=Morand aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=LouiseMennen kn-aut-sei=Louise kn-aut-mei=Mennen aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChristianR?m?sy kn-aut-sei=Christian kn-aut-mei=R?m?sy aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=AugustinScalbert kn-aut-sei=Augustin kn-aut-mei=Scalbert aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学薬学部 affil-num=2 en-affil= kn-affil=Unit? des Maladies M?taboliques et Micronutrients affil-num=3 en-affil= kn-affil=Unit? des Maladies M?taboliques et Micronutrients affil-num=4 en-affil= kn-affil=Unit? des Maladies M?taboliques et Micronutrients affil-num=5 en-affil= kn-affil=UMR INSERM U557/INRA/CNAM affil-num=6 en-affil= kn-affil=Unit? des Maladies M?taboliques et Micronutrients affil-num=7 en-affil= kn-affil=Unit? des Maladies M?taboliques et Micronutrients en-keyword=Polyphenols kn-keyword=Polyphenols en-keyword=Flavonoids kn-keyword=Flavonoids en-keyword=Phenolic acids kn-keyword=Phenolic acids en-keyword=High-throughput analysis kn-keyword=High-throughput analysis en-keyword=Urine kn-keyword=Urine en-keyword=Beverages kn-keyword=Beverages END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=薬用植物中の高度に酸化されたエラジタンニンに関する研究 kn-title=Studies on the Highly Oxidized Ellagitannins in Medicinal Plants en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoHideyuki en-aut-sei=Ito en-aut-mei=Hideyuki kn-aut-name=伊東秀之 kn-aut-sei=伊東 kn-aut-mei=秀之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END