start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=19 article-no= start-page=5901 end-page=5904 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A en-subtitle= kn-subtitle= en-abstract= kn-abstract=Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. en-copyright= kn-copyright= en-aut-name=IshimotoHidekazu en-aut-sei=Ishimoto en-aut-mei=Hidekazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataMari en-aut-sei=Shibata en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MyojinYuki en-aut-sei=Myojin en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItoHideyuki en-aut-sei=Ito en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaiAkihiro en-aut-sei=Tai en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima affil-num=7 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Ellagitannin kn-keyword=Ellagitannin en-keyword=Urolithin A kn-keyword=Urolithin A en-keyword=Antioxidant activity kn-keyword=Antioxidant activity en-keyword=Anti-inflammatory activity kn-keyword=Anti-inflammatory activity END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue= article-no= start-page=595 end-page=605 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=New dimeric flavans from gambir, an extract of Uncaria gambir en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Three new dimeric flavans, catechin-(4 alpha -> 8)-ent-epicatechin (7), gambirflavan D1 (8), and gambirflavan D2 (9), were isolated from gambir (an extract from the leaves and young twigs of Uncaria gambir), and their structures were determined based on spectroscopic and chemical data.

en-copyright= kn-copyright= en-aut-name=TaniguchiShoko en-aut-sei=Taniguchi en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaKayo en-aut-sei=Kuroda en-aut-mei=Kayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshikadoNaomi en-aut-sei=Yoshikado en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DoiKou-ichi en-aut-sei=Doi en-aut-mei=Kou-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanabeMasahiro en-aut-sei=Tanabe en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShibataTakashi en-aut-sei=Shibata en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaTakashi en-aut-sei=Yoshida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=2 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=4 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=5 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=6 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=7 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=8 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University en-keyword=PROCYANIDINS kn-keyword=PROCYANIDINS END