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ID 49566
フルテキストURL
著者
Teshigawara, Sanae
Wada, Jun Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci
Hida, Kazuyuki
Nakatsuka, Atsuko
Kanzaki, Motoko Kagawa Univ, Fac Med, Dept Hyg
Inoue, Kentaro
Terami, Takahiro
Katayama, Akihiro
Iseda, Izumi
Matsushita, Yuichi
Miyatake, Nobuyuki Kagawa Univ, Fac Med, Dept Hyg
McDonald, John F. Millipore Corp, Linco Res, St Charles
Hotta, Kikuko Kyoto Univ, Grad Sch Med, Evidenced Based Med Res Ctr
Makino, Hirofumi
抄録
Context: Vaspin is an adipokine with insulin-sensitizing effects identified from visceral adipose tissues of genetically obese rats. Objective: We investigated genetic and nongenetic factors that define serum concentrations of vaspin. Design, Setting and Participants: Vaspin levels were measured with RIA in Japanese subjects with normal fasting plasma glucose (NFG; n = 259) and type 2 diabetes patients (T2D; n = 275). Single nucleotide polymorphisms (SNP) at SERPINA12 (vaspin) gene locus were discovered, and five SNP were genotyped in the subjects with varied body mass index (n = 1138). Results: The level of serum vaspin in 93% of the samples was found to vary from 0.2 to nearly 2 ng/ml in NFG subjects (n = 259) and from 0.2 to nearly 3 ng/ml in T2D patients (n = 275) (Vaspin(Low) group), whereas a significant subpopulation (7%) in both groups displayed much higher levels of 10-40 ng/ml (Vaspin(High) group). In the Vaspin(Low) group, serum vaspin levels in T2D were significantly higher than healthy subjects (0.99 +/- 0.04 vs. 0.86 +/- 0.02 ng/ml; P < 0.01). Both in T2D and genotyped Japanese population, serum vaspin levels closely correlated with homeostasis model of assessment for insulin resistance rather than anthropometric parameters. By genotyping, rs77060950 tightly linked to serum vaspin levels, i.e. CC (0.6 +/- 0.4 ng/ml), CA (18.4 +/- 9.6 ng/ml), and AA (30.5 +/- 5.1 ng/ml) (P < 2 x 10(-16)). Putative GATA-2 and GATA-3 binding consensus site was found at rs77060950. Conclusions: Serum vaspin levels were related to insulin resistance, and higher levels of serum vaspin in 7% of the Japanese population are closely linked to minor allele sequence (A) of rs77060950. (J Clin Endocrinol Metab 97: E1202-E1207, 2012)
発行日
2012-07
出版物タイトル
Journal of Clinical Endocrinology & Metabolism
97巻
7号
出版者
Endocrine Soc
開始ページ
E1202
終了ページ
E1207
ISSN
0021-972X
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1210/jc.2011-3297
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/49133
言語
English
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT