Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia

Asada, Saori; Morita, Hiroshi; Toh, Norihisa; Masuda, Takuro; Ueoka, Akira; Miyamoto, Masakazu; Nakagawa, Koji; Nishii, Nobuhiro; Nakamura, Kazufumi; Yuasa, Shinsuke

doi:10.1002/joa3.70172

Permalink : https://ousar.lib.okayama-u.ac.jp/69120

ID	69120
フルテキストURL	fulltext.pdf 532 KB
著者	Asada, Saori Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry ORCID Morita, Hiroshi Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Toh, Norihisa Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Kaken ID researchmap Masuda, Takuro Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Ueoka, Akira Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Miyamoto, Masakazu Department of Cardiology, Kagawa Prefectural Central Hospital Nakagawa, Koji Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Nishii, Nobuhiro Kaken ID publons Nakamura, Kazufumi Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Kaken ID publons researchmap Yuasa, Shinsuke Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry
抄録	Background: Mitral annular disjunction (MAD) is linked to an increased risk of sudden cardiac death, but its association with ventricular arrhythmias (VAs) in Japanese patients is unclear. Methods: We retrospectively analyzed 129 Japanese patients with VAs and no overt structural heart disease who underwent echocardiography and cardiac MRI. Results: MAD was diagnosed in 7.0%, and in 14% of patients with VAs originating from the mitral valve apparatus. MAD was significantly associated with multifocal VAs, late gadolinium enhancement in the papillary muscles, and greater mitral regurgitation. Conclusion: MAD may be an important arrhythmogenic substrate in apparently idiopathic VAs among Japanese patients.
キーワード	arrhythmic mitral valve prolapses idiopathic ventricular arrhythmia late gadolinium enhancement mitral annular disjunction multifocal ventricular arrhythmia
発行日	2025-08
出版物タイトル	Journal of Arrhythmia
巻	41巻
号	4号
出版者	Wiley
開始ページ	e70172
ISSN	1880-4276
NCID	AA12059301
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
DOI	10.1002/joa3.70172
関連URL	isVersionOf https://doi.org/10.1002/joa3.70172
ライセンス	http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation	S. Asada, H. Morita, N. Toh, et al., “ Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia,” Journal of Arrhythmia 41, no. 4 (2025): e70172, https://doi.org/10.1002/joa3.70172.