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ID 31719
JaLCDOI
フルテキストURL
著者
Kondo, Asami Okayama University
Sakaguchi, Masakiyo Okayama University ORCID Kaken ID publons researchmap
Makino, Eiichi Okayama University
Namba, Masayoshi Okayama University
Okada, Shigeru Okayama University
Huh, Nam-ho Okayama University
抄録

Using 2-dimensional gel electrophoresis, we previously demonstrated that the S100C protein remarkably decreased after immortalization of normal human fibroblasts, and that this protein caused growth inhibition of human tumor cells when forcibly expressed in these cells, suggesting that S100C plays a significant role in tumor suppression. The present study was carried out to determine what type of human tissues express S100C protein, and, subsequently, whether the S100C content in these tissues changes after normal cells have been transformed into cancer cells. We found that ductal cells in various tissues were positively stained with the S100C protein. In comparison, epithelial cells in digestive organs such as the stomach, small intestine, and colon were not stained as strongly. When 14 pairs of human normal and cancerous tissues were stained with the antibody, decreases in the staining levels of S100C were observed in 6 kinds of cancerous tissues--from the bronchus, mammary duct, renal tubule, prostate, uterus, and testis--in comparison with staining in their normal counterparts. These results suggest that S100C is a new tumor marker protein, the expression of which significantly decreases after malignant transformation of human tissues.

キーワード
S100C-antibody
human tissues
immunostaining
Amo Type
Article
出版物タイトル
Acta Medica Okayama
発行日
2002-02
56巻
1号
出版者
Okayama University Medical School
開始ページ
31
終了ページ
34
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT