ID | 32953 |
フルテキストURL | |
著者 |
Maki, Yu
Okayama University
Asaumi, Jun-ichi
Okayama University
Kokeguchi, Susumu
Okayama University
Fukui, Kazuhiro
Okayama University
Kawai, Noriko
Okayama University
Tanaka, Noriaki
Okayama University
Matsubara, Nagahide
Okayama University
Kishi, Kanji
Okayama University
|
抄録 | The DNA repair enzyme, O-6-methylguanine-DNA methyltransferase (MGMT) modulates the effectiveness of alkylating agents. However, the relationship between MGMT and the sensitivities to other agents has not been explored. In the present study, the association between MGMT expression and the cellular sensitivity to the platinum agent, CDDP was examined in four human oral cancer cell tines. CDDP depleted MGMT protein and mRNA levels in all four cell tines. Two cell lines with low MGMT expression were sensitive to an alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine and CDDP, whereas two other cell tines with high MGMT expression were resistant to both agents. Furthermore, the addition of the MGMT inhibitor, O-6-benzylguanine (O-6-BG), invariably enhanced CDDP sensitivity. CDDP depleted MGMT expression, and CDDP sensitivity was enhanced by O-6-BG. These results provide valuable information about the relationship between MGMT expression and CDDP sensitivity in oral cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved. |
キーワード | mgmt
cddp
o-6-bg
oral cancer
|
備考 | Digital Object Identifer:10.1016/j.oraloncology.2005.05.011
Published with permission from the copyright holder. This is the institute's copy, as published in Oncology, July 2005, Volume 41, Issue 10, Pages 984-993. Publisher URL:http://dx.doi.org/10.1016/j.oraloncology.2005.05.011 Direct access to Thomson Web of Science record Copyright © 2005 Elsevier Ltd All rights reserved. All rights reserved. |
発行日 | 2005-7
|
出版物タイトル |
Oral Oncology
|
巻 | 41巻
|
号 | 10号
|
開始ページ | 984
|
終了ページ | 993
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
査読 |
有り
|
DOI | |
Web of Science KeyUT | |
Submission Path | dentistry_general/8
|