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ID 32089
JaLCDOI
フルテキストURL
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著者
Iwatsuki, Keiji Okayama University
Yamamoto, Takenobu Okayama University
Tsuji, Kazuhide Okayama University
Suzuki, Daisuke Okayama University
Fujii, Kazuyasu Okayama University
Matsuura, Hironori Okayama University
Oono, Takashi Okayama University
抄録

Epstein-Barr virus (EBV), or human herpesvirus 4 (HHV-4), infects the vast majority of adults worldwide, and establishes both nonproductive (latent) and productive (lytic) infections. Host immune responses directed against both the lytic and latent cycle-associated EBV antigens induce a diversity of clinical symptoms in patients with chronic active EBV infections who usually contain an oligoclonal pool of EBV-infected lymphocyte subsets in their blood. Episomal EBV genes in the latent infection utilize an array of evasion strategies from host immune responses: the minimized expression of EBV antigens targeted by host cytotoxic T lymphocytes (CTLs), the down-regulation of cell adhesion molecule expression, and the release of virokines to inhibit the host CTLs. The oncogenic role of latent EBV infection is not yet fully understood, but latent membrane proteins (LMPs) expressed during the latency cycle have essential biological properties leading to cellular gene expression and immortalization, and EBV-encoded gene products such as viral interleukin-10 (vIL-10) and bcl-2 homologue function to survive the EBV-infected cells. The subsequent oncogenic DNA damage may lead to the development of neoplasms. EBV-associated NK/T cell lymphoproliferative disorders are prevalent in Asia, but quite rare in Western countries. The genetic immunological background, therefore, is closely linked to the development of EBV-associated neoplasms.

キーワード
latent infection
hydroa vacciniforme
mosquito allergy
chronic active EB virus infection
hemophagocytic syndrome
Amo Type
Article
発行日
2004-08
出版物タイトル
Acta Medica Okayama
58巻
4号
出版者
Okayama University Medical School
開始ページ
169
終了ページ
180
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT