著者 Okui, Akemi| Soga, Yoshihiko| Kokeguchi, Susumu| Nose, Motoko| Yamanaka, Reiko| Kusano, Nobuchika| Morita, Manabu|
発行日 2015-07-15
出版物タイトル Internal Medicine
54巻
14号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52405
フルテキストURL 68_2_89.pdf
著者 Sako, Shinichi| Kariyama, Reiko| Mitsuhata, Ritsuko| Yamamoto, Masumi| Wada, Koichiro| Ishii, Ayano| Uehara, Shinya| Kokeguchi, Susumu| Kusano, Nobuchika| Kumon, Hiromi|
抄録 We conducted a study on molecular epidemiology and clinical implications of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolated from urine. Over a 10-year period from 2001 through 2010, a total of 92 MBL-producing P. aeruginosa urine isolates were collected from patients (one isolate per patient) who were admitted to 5 hospitals in Okayama Prefecture, Japan. When cross-infection was suspected in the hospital, pulsed-field gel electrophoresis was performed. In the resulting dendrogram of 79 MBL-producing P. aeruginosa urine isolates, no identical isolates and 7 pairs of isolates with ≥80% similarity were found. The biofilm-forming capabilities of 92 MBL-producing P. aeruginosa urine isolates were significantly greater than those of 92 non-MBL-producing urine isolates in a medium of modified artificial urine. The imipenem resistance transferred in 16 of 18 isolates tested, and these frequencies were in the range of 10-3 to 10-9. All of 18 isolates tested belonged to internationally spread sequence type 235 and had 3 gene cassettes of antimicrobial resistance genes in the class 1 integron. The strong biofilm-forming capabilities of MBL-producing P. aeruginosa urine isolates could be seriously implicated in nosocomial infections. To prevent spread of the organism and transferable genes, effective strategies to inhibit biofilm formation in medical settings are needed.
キーワード Pseudomonas aeruginosa metallo-β-lactamase molecular epidemiology biofilm urinary tract infection
Amo Type Original Article
発行日 2014-04
出版物タイトル Acta Medica Okayama
68巻
2号
出版者 Okayama University Medical School
開始ページ 89
終了ページ 99
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol68/iss2/4
PubMed ID 24743784
Web of Sience KeyUT 000334652700004
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52504
著者 Sugiura, Yuko| Soga, Yoshihiko| Yamabe, Kokoro| Tsutani, Soichiro| Tanimoto, Ichiro| Maeda, Hiroshi| Kokeguchi, Susumu| Fujii, Nobuharu| Ishimaru, Fumihiko| Tanimoto, Mitsune| Nishimura, Fusanori| Takashiba, Shogo|
発行日 2010-03
出版物タイトル Supportive Care in Cancer
18巻
3号
資料タイプ 学術雑誌論文
著者 Sugiura, Yuko| Soga, Yoshihiko| Tanimoto, Ichiro| Kokeguchi, Susumu| Nishide, Sachiko| Kono, Kotoe| Takahashi, Kanayo| Fujii, Nobuharu| Ishimaru, Fumihiko| Tanimoto, Mitsune| Yamabe, Kokoro| Tsutani, Soichiro| Nishimura, Fusanori| Takashiba, Shogo|
発行日 2008-04
出版物タイトル Supportive Care in Cancer
16巻
4号
資料タイプ 学術雑誌論文
著者 Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
発行日 2005-7
出版物タイトル Oral Oncology
41巻
10号
資料タイプ 学術雑誌論文
著者 Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
発行日 2005-07
出版物タイトル Cancer Chemotherapy and Pharmacology
56巻
1号
資料タイプ 学術雑誌論文
著者 苔口 進|
発行日 1992-03-28
出版物タイトル
資料タイプ 学位論文