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ID 55213
フルテキストURL
著者
Kudo, Ken-ichi
Hanafusa, Tadashi Department of Radiation Research, Advanced Science Research CenterOkayama University ORCID Kaken ID publons researchmap
Ono, Toshiro Department of Radiation Research, Advanced Science Research CenterOkayama University Kaken ID researchmap
抄録
Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes. They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.
キーワード
Monoterpenes
Linalool
X-ray irradiation
Reactive oxygen species
SSB
備考
The final publication is available at Springer
発行日
2017-07
出版物タイトル
Journal of Radioanalytical and Nuclear Chemistry
313巻
1号
出版者
Springer
開始ページ
169
終了ページ
174
ISSN
0236-5731
NCID
AA11120189
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
論文のバージョン
author
DOI
関連URL
https://doi.org/10.1007/s10967-017-5268-0