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ID 59917
フルテキストURL
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著者
Ohtsuki, Takashi Department of Medical Technology, Graduate School of Health Sciences, Okayama University ORCID Kaken ID publons researchmap
Hatipoglu, Omer F. Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Asano, Keiichi Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Inagaki, Junko Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Nishida, Keiichiro Department of Orthopaediac Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Hirohata, Satoshi Department of Medical Technology, Graduate School of Health Sciences, Okayama University ORCID Kaken ID researchmap
抄録
In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1 beta (IL-1 beta) stimulation in chondrocytic cells. We also observed that ERK activation and NF-kappa B nuclear translocation were involved in the induction of CEMIP by IL-1 beta. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1 beta-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.
キーワード
cell migration-inducing hyaluronidase 1 (CEMIP)
chondrocyte
hyaluronan
mechanical strain
nuclear factor kappa B (NF-kappa B)
osteoarthritis
発行日
2020-04-29
出版物タイトル
International Journal of Molecular Sciences
21巻
9号
出版者
MDPI
開始ページ
3140
ISSN
1422-0067
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 by the authors.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3390/ijms21093140
ライセンス
http://creativecommons.org/licenses/by/4.0/
助成機関名
日本学術振興会
助成番号
17K19727
17H04313
19K09627
19K11791