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ID 34120
フルテキストURL
Thumnail figsPI.pdf 145 KB
著者
Hisakane, Naoto Department of Human Ecology, Graduate School of Environmental Science, Okayama University
Kirinoki, Masashi Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine
Chigusa, Yuichi Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine
Sinuon, Muth National Center for Parasitology, Entomology and Malaria Control, Ministry of Health
Socheat, Duong National Center for Parasitology, Entomology and Malaria Control, Ministry of Health
Matsuda, Hajime Institute of International Education and Research, Dokkyo Medical University School of Medicine
Ishikawa, Hirofumi Department of Human Ecology, Graduate School of Environmental Science, Okayama University,
抄録

We constructed a mathematical model for the transmission of Schistosoma mekongi in Cambodia. The simulation of the model will be instrumental in planning schistosomiasis control measures. The model includes two definitive hosts, humans and dogs, as animal reservoirs. Dogs are recognized to play an important role in schistosomiasis transmission in Cambodia. For the purpose of dealing with age-specific prevalence and intensity of infection, the human population was classified into eight age categories in the model. To describe the seasonal fluctuation of the intermediate host population of S. mekongi, the "Post-Spate Survival" hypothesis was adopted for the population dynamics of Neotricula aperta present in the Mekong River. We carried out simulations to evaluate the effect of universal treatment (UT) and targeted mass treatment (TT) with praziquantel on the reduction in prevalence of S. mekongi. The simulations indicated that biyearly UT for 8 years or yearly TT for 5 years after three courses of yearly UT could reduce the prevalence to below 5% when a UT or TT coverage of 85% of inhabitants was achieved. The simulation suggested that the suppression of S. mekongi in Cambodia would be possible by UT or TT with a high coverage rate.

キーワード
Schistosoma mekongi
Cambodia
mathematical model
Neotricula aperta
Mekong River
備考
Published with permission from the copyright holder.
This is a author's copy,as published in PARASITOLOGY INTERNATIONAL , 2008, volume 57, issue 3, pp 379-385.
Publisher URL: http://dx.doi.org/10.1016/j.parint.2008.03.003
Direct access to Thomson Web of Science record
Copyright © 2008 Elsevier Ireland Ltd. All rights reserved.
発行日
2008-09-03
出版物タイトル
PARASITOLOGY INTERNATIONAL
57巻
3号
資料タイプ
学術雑誌論文
言語
English
査読
有り
DOI
Web of Sience KeyUT
Submission Path
microbiology_and_immunology/10