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ID 52429
フルテキストURL
タイトル(別表記)
Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders
著者
眞田 敏 岡山大学教育学部障害児教育講座
浅野 孝 Department of Child Neurology,Okayama University Medical School
岡 鍈次 Department of Child Neurology,Okayama University Medical School
河原 道子 Department of Radiology,Okayama University Medical School
栄 勝美 Department of Radiology,Okayama University Medical School
平木 祥夫 Department of Radiology,Okayama University Medical School
大田原 俊輔 Kibi International University Health Sciences School
抄録
Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA),creatine (Cr) and choline (Ch). Hence,clinical applications of this method for neuropediatric diseases can be expected. However,regarding neuronal migration disorders,there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders,ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr,Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ~ 3 × 3 × 5cm3 was chosen in the area including lesions,and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41,1.95,2.27 and 1.71 in cases with heterotopic gray matter,0.99 in one case with polymicrogyria,an d 1.30 in one case with hemimegalencephaly,contrasted with a contralataral area without lesions: 1.89, 2.89,2.87,2.55,3.26,2.03,respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population,or reduced metabolism in the lesions.
キーワード
MR spectroscopy
migration disorder
heterotopic gray matter
polymicrogyria
hemimegalencephaly
発行日
1999
出版物タイトル
岡山大学教育学部研究集録
出版物タイトル(別表記)
Bulletin of Faculty of Education, Okayama University
110巻
1号
出版者
岡山大学教育学部
出版者(別表記)
Faculty of Education, Okayama University
開始ページ
29
終了ページ
34
ISSN
0471-4008
NCID
AN00032875
資料タイプ
紀要論文
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
bgeou