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ID 31590
JaLCDOI
フルテキストURL
著者
Segawa, Yoshihiko Okayama Univresity
Ohnoshi, Taisuke Okayama University
Hiraki, Shunkichi Okayama Red Cross Hospital
Ueoka, Hiroshi Okayama University
Kiura, Katsuyuki Okayama University
Kamei, Haruhito Okayama University
Tabata, Masahiro Okayama University
Shibayama, Takuo Okayama University
Miyatake, Kazuyo Okayama University
Genda, ken-ichi Okayama University
Matsumura, Tadashi Okayama University
Kimura, Ikuro Okayama University
抄録

In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.

キーワード
small cell lung cancer
immunohistochemistry
drug resistance
P-glycoprotein
carcinoembryonic antigen
Amo Type
Article
発行日
1993-06
出版物タイトル
Acta Medica Okayama
47巻
3号
出版者
Okayama University Medical School
開始ページ
181
終了ページ
189
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT