ID | 48713 |
フルテキストURL | |
著者 |
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Yoshimoto, Masaaki
Graduate School of Health Sciences, Okayama University
Nakagawa, Shinya
Graduate School of Health Sciences, Okayama University
Mizuguchi, Yuko
Radiation Safety Research Center, Central Research Institute of Electric Power Industry
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
Kaken ID
publons
researchmap
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抄録 | We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.
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キーワード | organ transplantation
low-dose irradiation
antioxidative function
hepatopathy
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発行日 | 2009-09
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出版物タイトル |
Journal of Clinical Biochemistry and Nutrition
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巻 | 45巻
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号 | 2号
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出版者 | The Editorial Secretariat of JCBN
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開始ページ | 219
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終了ページ | 226
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ISSN | 0912-0009
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NCID | AA10710201
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/jcbn/45/2/45_09-06/_article
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言語 |
英語
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著作権者 | Copyright © 2009 by The Editorial Secretariat of JCBN
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |