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ID 47009
JaLCDOI
フルテキストURL
Thumnail 65_5_279.pdf 5.06 MB
著者
Miyoshi, Ko Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kasahara, Kyosuke Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyazaki, Ikuko Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Asanuma, Masato Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors.
キーワード
primary cilium length
lithium
cyclic AMP
soluble tubulin
intraflagellar transport
Amo Type
Review
発行日
2011-10
出版物タイトル
Acta Medica Okayama
65巻
5号
出版者
Okayama University Medical School
開始ページ
279
終了ページ
285
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT