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ID 32031
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.74 MB
著者
Aoki, Sogawa Chiharu Okayama University
Asanuma, Masato Okayama University
Sogawa, Norio Okayama University
Miyazaki, Ikuko Okayama University
Nakanishi, Tohru Okayama University
Furuta, Hiroaki Okayama University
Ogawa, Noriko Okayama University
抄録

The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.

キーワード
neuroprotectin
metal transport
localization
gene expression
neurodegenerative disease
Amo Type
Review
発行日
2001-02
出版物タイトル
Acta Medica Okayama
55巻
1号
出版者
Okayama University Medical School
開始ページ
1
終了ページ
9
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT