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ID 52028
フルテキストURL
著者
Komatsu, Seiji Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg
Wakabayashi, Taketoshi Okayama Univ, Grad Sch Med, Dept Cytol & Histol
Yamada, Kiyoshi Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg
Matsumoto, Kumiko Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg
Kimata, Yoshihiro Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg Kaken ID
Kosaka, Jun Kansai Med Univ, Dept Anat & Cell Sci
抄録
We investigated whether the use of vascularized peripheral nerve grafts on the optic nerve stump enhances axonal regeneration of retinal ganglion cells compared with isolated nonvascularized grafts. The rat median nerve was microsurgically sutured with its supplying artery and vein to the optic nerve stump. The number of retinal ganglion cells with regenerating axons was evaluated by retrograde labeling into the grafted peripheral nerve, and the myelination of the regenerating axon fibers was examined by electron microscopy. The number of retinal ganglion cells with regenerating axons was significantly higher in the vascularized graft than in the nonvascularized graft. The ratio of myelinated axon fibers was also increased in vascularized grafts. Thus, grafting with their supplying arteries and veins to an injured nerve stump represents a promising strategy to accelerate axonal regeneration from neurons of the central nervous system.
キーワード
graft
microsurgery
optic nerve
retinal ganglion cells
Schwann cells
vascularized nerve
発行日
2013-07-10
出版物タイトル
NeuroReport
24巻
10号
開始ページ
566
終了ページ
571
ISSN
0959-4965
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1097/WNR.0b013e3283625b39
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51959
言語
English
著作権者
(C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT