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ID 31310
JaLCDOI
フルテキストURL
著者
Tamura, Makoto Okayama University
Ueoka, Hiroshi Okayama University
Kiura, Katsuyuki Okayama Univeristy
Tabata, Masahiro Okayama University
Shibayama, Takuo Okayama University
Miyatake, Kazuyo Okayama University
Genba, Kenichi Okayama University
Hiraki, Shunkichi Okayama Cross Hospital
harada, Mine Okayama University
抄録

In order to elucidate factors influencing the prognosis of small-cell lung cancer (SCLC), we reviewed the records of 253 patients with SCLC and evaluated 20 pretreatment prognostic factors by univariate analysis and Cox's multiple regression analysis. Recursive partitioning and amalgamation (RPA) was employed to identify subgroups with similar survival rates. Cox's multiple regression analysis identified five significant factors: extent of disease, number of metastatic sites, serum albumin, serum lactate dehydrogenase, and presence of weight loss. Among these, extent of disease was the most influential factor. RPA analysis revealed three subgroups predicting significantly different prognoses. The median survival time and 3-year survival rate were 18.4 months and 20.6%, respectively for the good-risk group (limited disease without weight loss), 13.5 months and 9.1%, respectively for the intermediate-risk group (limited disease with weight loss or extensive disease with less than two metastatic sites), and 9.2 months and 0%, respectively for the poor-risk group (extensive disease with two or more metastatic sites). These results will be useful for development of new staging system or subsequent stratification for randomized trials.

キーワード
prognostic factors
Cox's multiple regression analysis
recursive partitioning and amalgamayion method
small-sell lung canser
Amo Type
Article
発行日
1998-04
出版物タイトル
Acta Medica Okayama
52巻
2号
出版者
Okayama University Medical School
開始ページ
105
終了ページ
111
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT