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ID 30419
JaLCDOI
フルテキストURL
著者
Yamauchi, Takayoshi Okayama University
Ogura, Toshio Okayama University
Oishi, Tetsuya Okayama Univresity
Harada, Kazushi Okayama University
Hashimoto, Masami Okayama University
Mimura, Yukari Okayama University
Asano, Naoko Okayama University
Ota, Zensuke Okayama University
Kageyama, Jingo Okayama University
抄録

To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR.

キーワード
vasopressin
V1 and V2 receptor antagonist
hypertension
pressor response
OPC-31260
Amo Type
Article
発行日
1995-02
出版物タイトル
Acta Medica Okayama
49巻
1号
出版者
Okayama University Medical School
開始ページ
53
終了ページ
59
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT