JaLCDOI 10.18926/AMO/32274
フルテキストURL fulltext.pdf
著者 Hirotsune, Nobuyuki| Kinugasa, Kazushi| Mandai, Shinya| Tokunaga, Koji| Handa, Akira| Kawada, Sanami| Ohmoto, Takashi|
抄録 <p>Cellulose acetate polymer (CAP) solution is a new liquid embolic material, and it has been used clinically for the thrombosis of cerebral aneurysms. The purpose of the study was to test a method of aneurysm treatment. In an experimental model, retrievable interlocking detachable coils (IDCs) were used to create an intraaneurysmal frame or prop and then CAP was injected into 20 experimentally induced canine cervical aneurysms. Intraaneurysmal thrombosis was induced 1 week after aneurysm creation. Complete thrombosis was attempted in 12 aneurysms, and partial thrombosis was attempted in 4. Four other aneurysms served as controls. Follow-up angiography was performed for up to 8 weeks, and with the exception of 4 aneurysms, which were kept for a 2-year long-term follow-up study, the aneurysms were then harvested for histological examination. Thrombosis was successfully achieved in all cases except for 2 enlarged aneurysms that were initially partially thrombosed. No thromboembolism to distal vessels was observed. No compaction or shift of the CAP-IDC complex occurred even after 2 years. Histologically, CAP and IDCs conformed to the massive thrombotic complex without any fragmentation. By creating a frame or prop with retrievable microcoils, we were able to inject the CAP implies a comparison safely and precisely than has been previously reported. Our findings suggest that this method will be useful for the treatment of cerebral aneurysms.</p>
キーワード experimentally induced aneurysm cellulose acetate polymer (CAP) interlocking detachable coil (IDC) endovascular technique
Amo Type Article
発行日 2000-08
出版物タイトル Acta Medica Okayama
54巻
4号
出版者 Okayama University Medical School
開始ページ 153
終了ページ 164
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol54/iss4/3
PubMed ID 10985175
Web of Sience KeyUT 000089132800003
JaLCDOI 10.18926/AMO/31858
フルテキストURL fulltext.pdf
著者 Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
抄録 <p>Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this &#34;11R&#34;, all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).</p>
キーワード cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP)
Amo Type Review
発行日 2009-02
出版物タイトル Acta Medica Okayama
63巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 7
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol63/iss1/1
PubMed ID 19247417
Web of Sience KeyUT 000263730300001
著者 小川 智之| 小野 成紀| 市川 智継| 有光 帥二| 小野田 惠介| 徳永 浩司| 杉生 憲志| 富澤 一仁| 松井 秀樹| 伊達 勲|
発行日 2008-08-01
出版物タイトル 岡山医学会雑誌
120巻
2号
資料タイプ 学術雑誌論文
著者 徳永 浩司|
発行日 1998-12-31
出版物タイトル
資料タイプ 学位論文