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タイトル(別表記)
Effect of postprandial hyperglycemia and hyperinsulinemia on vascular responsiveness
著者
座間味 義人 岡山大学大学院医歯薬学総合研究科臨床薬学分野
高取 真吾 日本新薬(株)創薬研究所
岩谷 有希子 岡山大学大学院医歯薬学総合研究科臨床薬学分野
山脇 康佑 岡山大学大学院医歯薬学総合研究科臨床薬学分野
宮下 智子 岡山大学大学院医歯薬学総合研究科臨床薬学分野
藪前 奈々 岡山大学大学院医歯薬学総合研究科臨床薬学分野
高山 房子 岡山大学大学院医歯薬学総合研究科臨床薬学分野
見尾 光庸 就実大学薬学部薬効解析学分野
川﨑 博己 岡山大学大学院医歯薬学総合研究科臨床薬学分野
抄録
Recent clinical studies demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension. Therefore, we investigated influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. Changes in vascular responses to spinal cord stimulation (SCS) and intravenous bolus injections of noradrenaline, angiotensin II, calcitonin generelated peptide (CGRP), acetylcholine and sodium nitroprusside (SNP) were studied by infusing various concentration of glucose or insulin. Continuous glucose infusion, which increased both blood glucose and serum insulin levels, significantly augmented adrenergic nerve-mediated pressor responses to SCS without affecting injection of pressor responses to noradrenaline or angiotensin II. In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP. In pithed rats treated with octreotide, which increased blood glucose without increasing serum insulin levels, glucose infusion caused only significant augmentation of adrenergic nervemediated pressor responses. Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemic, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses. The present results suggest that acute hyperglycemia and hyperinsulinemia increases adrenergic nerve-mediated vasoconstriction, which is partly associated with the blunted CGRPergic nerve function, and that plasma insulin concentration associated with hyperglycemia may be responsible for alteration of neuronal vascular regulation.
キーワード
hyperglycemia
hyperinsulinemia
Calcitonin gene-related peptide nerve
備考
コンテンツの著作権は日本薬学会が有します。
発行日
2008-03-01
出版物タイトル
藥學雜誌
出版物タイトル(別表記)
Yakugaku zasshi
128巻
3号
出版者
日本薬学会
出版者(別表記)
The Pharmaceutical Society of Japan
開始ページ
419
終了ページ
424
ISSN
00316903
NCID
AN00284903
資料タイプ
学術雑誌論文
言語
Japanese
著作権者
日本薬学会
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT